Potential activities for constituents from Vicia faba

Trends in Phytochemical Research

مقاله 3، دوره 2، شماره 1، خرداد 2018، صفحه 21-26   

نوع مقاله: Original Article

نویسندگان

Ahmed Allam^{* 1، 2}؛ Alaa Nafady²؛ Amgad I.M. Khedr³؛ Toshinori Nakagawa¹؛ Kuniyoshi Shimizu¹

¹Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

²Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

³Department of Pharmacognosy, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt

چکیده

A survey of phytochemical and biological investigation of Vicia faba L. flowers resulted in isolation of polyphenolic and nitrogenous compounds; Kaempferol -3-O-α-D-galactopyranosyl 7-O-α-L-rhamnopyranoside 1, kaempferol 3-O-(3"-O-α-L-rhamnopyranosyl)-α-L-rhamnopyranoside 2, kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-galactopyranoside-7- O-α-L -rhamnopyranoside 3, allantoin 4 and adenosine 5. For 1-3, it is the first report of their isolation from Vicia faba L.
The structure of the isolated compounds has been characterized on the basis of spectroscopic methods in addition to comparison with literature data. These compounds along with methanol extract were tested to evaluate their antioxidant activity estimated by oxygen radical absorption capacity (ORAC) assay and anti-allergic activities through inhibition of β-hexosaminidase enzyme. For the antioxidant activity, both methanolic extract and the isolated compounds exhibited a high activity ranged from 3.1 - 9.6 mg TE/mg extract. For the antiallergic activity, it was noticed that all the tested compounds and methanol extract have good inhibition for β-hexosaminidase release without affecting the cell viability where the production of β-hexosaminidase was decreased to about 69 - 82 %. These results revealed that the methanol extract and its isolated compounds of Vicia faba L. flowers had high antioxidant and high anti-allergic activities. It is expected that Vicia faba L. flowers could be used for the treatment of oxidative stress and will find new and high-value-added uses in cosmetics.

کلیدواژه‌ها

Anti-allergic activity؛ Flavonoid glycosides؛ ORAC activity؛ Vicia faba L

سایر فایل های مرتبط با مقاله

Supplementary file.pdf

مراجع

Aidi Wannes, W., Mhamdi, B., Saidani Tounsi, M., Marzouk, B., 2017. Lipid and volatile composition of borage (Borago officinalis L.) leaf. Trends Phytochem. Res. 1(3), 143-148.

Bouchenak, M., Lamri-Senhadji, M., 2013. Nutritional quality of legumes, and their role in cardiometabolic risk prevention: a review. J. Med. Food. 16(3), 1-14.

Boukhanouf, S., Louaileche, H., Perrin, D., 2016. Phytochemical content and in vitro antioxidant activity of faba bean (V. faba L.) as affected by maturity stage and cooking practice. Int. Food Res. J. 23(3): 954-961.

Camilo, C.J., Alves Nonato, C.d.F., Galvão-Rodrigues, F.F., Costa, W.D., Clemente, G.G., Sobreira Macedo, M.A.C., Galvão Rodrigues, F.F., da Costa, J.G.M., 2017. Acaricidal activity of essential oils: a review. Trends Phytochem. Res. 1(4), 183-198.

Du, G., Sun, L., Zhao, R., Du, L., Song, J., Zhang, L., He, G., Zhang, Y., Zhang, J., 2016. Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease. Pharmacol. Ther. 162, 23-34.

 Frezza, C., Venditti, A., Serafini, I., Carassiti, A., Foddai, S., Bianco, A., Serafini, M., 2017. Phytochemical characteristics of Galeopsis ladanum subsp. angustifolia (Ehrh. ex Hoffm.) Gaudin collected in Abruzzo region (Central Italy) with chemotaxonomic and ethnopharmacological implications. Trends Phytochem. Res. 1(2), 61-68.

Garrett, A., Murray, B., Robison, R., O'Neill, K., 2010. Measuring antioxidant capacity using the ORAC and TOSC assays. Methods Mol. Biol. 594, 251-262.

Gvazava, L., Gorgaslidze, N., Ganzera, M., Skhirtladze, A., 2017. A new lupane triterpene glycoside from Euphorbia boissierana Prokh. Trends Phytochem. Res. 1(3), 149-152.

Halabalaki, M., Urbain, A., Paschali, A., Mitakou, S., Tillequin, F., Skaltsounis, A., 2011. Quercetin and kaempferol 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside]-7-O-α-L-rhamnopyranosides from Anthyllis hermanniae: structure determination and conformational studies. J. Nat. Prod. 74(9), 1939-1945.

Hyo-Hyun, P., Soyoung, L., Hee-Young, S., Seung-Bin, P., Mi-Sun, K., Eun-Ju, C., Thoudam, S., Jeoung-Hee, H., Maan-Gee, L., Jung-Eun, K., Myung, H., Taeg, K., Yeo, K., Sang-Hyun, K., 2008. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch. Pharm. Res. 31 (10), 1303-1311.

Jakub, T., Karel, S., 2016. Flavonoids as potent scavengers of hydroxyl radicals. Compr. Rev. Food Sci. Food Saf. 15(4), 720-738.

Jiaju, Z., Guirong, X., Xinjian, Y., 2011. Encyclopedia of Traditional Chinese Medicines - Molecular Structures. Springer Science & Business Media. 4, p. 423.

Jiang, Y., Wong, J., Fu, M., Ng, T., Liu, Z., Wang, C., Li, N., Qiao, W., Wen, T., Liu, F., 2011. Isolation of adenosine, iso-sinensetin and dimethylguanosine with antioxidant and HIV-1 protease inhibiting activities from fruiting bodies of Cordyceps militaris.Phytomedicine 18(2-3), 189-93.

Kapinová, A., Kubatka, P., Kružliak, P., Mokáň, M., Péč, M., Kassayová, M., Bojková, B., Dobrota, D., 2015. Chlorella pyrenoidosa, young barley and fruit peel polyphenols in rat breast cancer model - the effects on plasma lipid metabolism. Biologia (Bratisl) 70(2), 268-272.

María, L., Elena, F., Herminia, D., 2015. Relevance of natural phenolics from grape and derivative products in the formulation of cosmetics. Cosmetics 2(3), 259-276.

Mohammadhosseini, M., 2017a. The ethnobotanical, phytochemical and pharmacological properties and medicinal applications of essential oils and extracts of different Ziziphora species. Ind. Crops Prod. 105, 164-192.

Mohammadhosseini, M., 2017b. Essential oils extracted using microwave-assisted hydrodistillation from aerial parts of eleven Artemisia species: Chemical compositions and diversities in different geographical regions of Iran. Rec. Nat. Prod. 11(2), 114-129.

Mohammadhosseini, M., Akbarzadeh, A., Flamini, G., 2017. Profiling of compositions of essential oils and volatiles of Salvia limbata using traditional and advanced techniques and evaluation for biological activities of their extracts. Chem. Biodivers. 14(5), 10.1002/cbdv.201600361.

Mohammadhosseini, M., Akbarzadeh, A., Hashemi-Moghaddam, H., Mohammadi Nafchi, A., Mashayekhi, H.A., Aryanpour, A., 2016. Chemical composition of the essential oils from the aerial parts of Artemisia sieberi by using conventional hydrodistillation and microwave assisted hydrodistillation: A comparative study. J. Essent. Oil-Bear. Plants 19(1), 32-45.

Mohammadhosseini, M., Sarker, S.D., Akbarzadeh, A., 2017. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review. J. Ethnopharmacol. 199, 257-315.

Mulvihill, EE., Huff, MW., 2010. Antiatherogenic propertises of flavonoids: Implications for cardiovascular health. Can. J. Cardiol. 26, 17-21.

Petpiroon, N., Suktap, C., Pongsamart, S., Chanvorachote, P., Sukrong, S., 2015. Kaempferol-3-O-rutinoside from Afgekia mahidoliae promotes keratinocyte migration through FAK and Rac1 activation. J. Nat. Med. 69(3), 340-348.

Piotr, G., Cristina, M., Małgorzata, K., Juana, F., 2014. Non-nutritive compounds in Fabaceae family seeds and the improvement of their nutritional quality by traditional processing - a review. Pol. J. Food Nutr. Sci. 64(2), 75-89.

Qianqian, L., Yanna, C., Chuanqing, Z., Fengshan, W., 2015. Inhibition of the IgE-Mediated activation of RBL-2H3 cells by TIPP, a novel thymic immunosuppressive pentapeptide. Int. J. Mol. Sci. 16(1), 2252-2268.

Rocha, V., Ras, R., Gagliardi, A., Mangili, L., Trautwein, E., Santos, R., 2016. Effects of phytosterols on markers of inflammation: A systematic review and meta-analysis. Atherosclerosis 248, 76-83.

Roy, M., Koide, M., Rao, T., Okubo, T., Ogasawara, Y., Juneja, L., 2010. ORAC and DPPH assay comparison to assess antioxidant capacity of tea infusions: relationship between total polyphenol and individual catechin content. Int. J. Food Sci. Nutr. 61(2), 109-124.

Sarker, S.D., Nahar, L., Nurunnabi, T.R., Rahman, S.M.M., Sohrab, M.H., Billah, M.M., Ismail, F.M.D., Sharples, G.P., 2017. A mini-review on oxysporone. Trends Phytochem. Res. 1(2), 55-60.

Seif, G.,Solafa, A., Awadalla, A., Isam, A., 2015. Yield and quality attributes of faba bean inbred lines grown under marginal environmental conditions of Sudan. Food Sci. Nutr. 3(6), 539-547.

Shubashini, K., Poongothai, G., Pottail, L., 2011. Allantoin from the leaves of Pisonia grandis. Int. J. Pharm. Life Sci. 2(6), 815-817.

Sultana, S., Ali, M., Jameel, M., 2017. Phytochemical investigation and isolation of new compounds from the stems of Tinospora cordifolia Miers. Trends Phytochem. Res. 1(2), 83-92.

Taehun, L., Jaeyoung, K., Dongho, L., Woongchon, M., 2015. Effects of Cudrania tricuspidata fruit extract and its active compound, 5,7,3′,4′-tetrahydroxy-6,8-diprenylisoflavone, on the high-affinity IgE receptor-mediated activation of syk in mast cells. J. Agric. Food. Chem. 63(22), 5459-5467.

Xu, LR., Zhou, P., Zhi, YE., Wu, J., Zhang, S., 2009. Three new flavonol triglycosides from Derris trifoliata. J. Asian Nat. Prod. Res. 11(1), 79-84.

Yun, S., Kang, M., Park, J., Nam, S., 2010. Comparison of anti-allergenic activities of various polyphenolss in cell assays. J. Appl. Biol. Chem. 53, 139-146.