Biological application of Layered double hydroxides in drug delivery systems

Journal of Nanoanalysis

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 مرداد 1397

نوع مقاله: Review Paper

شناسه دیجیتال (DOI): 10.22034/jna.2018.567196.1088

نویسندگان

nahid shahabadi^{* 1}؛ Mahtab Razlansari²

¹razi university

²Chemistry department, institute of nanotechnology, razi university, Kermanshah, iran

چکیده

This review focuses on the extensive study of different layer double hydroxides (LDHs) nanostructures and also their biological and physicochemical (in vitro) properties to encapsulate and deliver drugs with a recognized pharmacokinetic profile in a sustained/modified manner for better remedial efficacy contrasted to the corresponding conventional treatments using free drugs. LDHs known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled‐release. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy.Development of new pharmaceutical formulations is observed, based on LDHs, for cancer therapy.

کلیدواژه‌ها

Layered double hydroxides؛ Biological application؛ Drug delivery؛ Release study