Anti-Quorum Sensing Potential of Potato Rhizospheric Bacteria

Journal of Chemical Health Risks

مقاله 4، دوره 7، شماره 1، فروردین 2017، صفحه 39-47   

شناسه دیجیتال (DOI): 10.22034/jchr.2017.544163

نویسندگان

Adeleh Sobhanipour^{* 1}؛ Keivan Behboudi²؛ Esmaeil Mahmoudi³؛ Mohsen Farzaneh⁴

¹Department of Plant Protection, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran

²Department of Plant Protection, College of Agriculture and Natural Resources, University of Tehran, Karaj,

³Department of Plant Protection, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran Transgenesis Center of Excellence, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan

⁴Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran

چکیده

The occurrence of antibiotic-resistant pathogenic bacteria is becoming a serious problem. The rise of multiresistance strains has forced the pharmaceutical industry to come up with new generation of more effective and potent antibiotics, therefore creating development of antivirulence compounds. Due to extensive usage of cell-to-cell bacterial communication (QS) systems to monitor the production of virulence factors, disruption of QS system results in creation of a promising strategy for the control of bacterial infection. Numerous natural quorum quenching (QQ) agents have been identified. In addition, many microorganisms are capable of producing smaller molecular QS inhibitors and/or macromolecular QQ enzymes. In present survey, anti QS activity of 1280 rhizosphere bacteria was assessed using the Pectobacterium carotovorum as AHL-donor and Chromobacterium violaceum CV026 as biosensor system. The results showed that 61 strains had highly AHL-degrading activity. Both Lux I and Lux R activity were affected by some isolates, suggesting that the rhizobacteria target both QS signal and receptor. These soil microorganisms with their anti-QS activity have the potential to be novel therapeutic agents for reducing virulence and pathogenicity of antibiotic resistant bacteria.

کلیدواژه‌ها

Antibiotic resistance؛ AHL؛ Rhizobacteria؛ Anti QS

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