Chemical Composition of the Essential Oil, Total Phenolic Content and Antioxidant Activity of Vitex pseudo-negundo Seeds Collected from Northeastern Iran

Journal of Chemical Health Risks

مقاله 5، دوره 7، شماره 3، آذر 2017   

شناسه دیجیتال (DOI): 10.22034/jchr.2017.544183

نویسندگان

Hashem Akhlaghi^{* 1}؛ Sedighe Sadat Akhlaghi²؛ Seyed Abolfazl Mousavi³

¹Department of Chemistry, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran

²Department of Nephrology, Shahid Beheshti Medical University, Tehran, Iran

³Undergraduate Student of Medicinal Chemistry, Department of Chemistry, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran

چکیده

In this study, the essential oil obtained by hydrodistillation of the seeds of Vitex pseudo-negundo (Verbenaceae), growing wild in Sabzevar, Khorasan Razavi Province, Iran, were analyzed by GC and GC/MS. The yield of total volatiles was 0.8% (w/w). Thirty-seven compounds representing 92.4% of the seed oil were identified. The main components of the oil were hexadecanoic acid (8.0%), elemol (7.0%) and α-bisabolol (6.1%). The oil was rich in sesquiterpene hydrocarbons (51.2%). The total flavonoids of different extracts of the plant were found the range 56-195 mg/g, with the maximum amount being in the methanol extract. In addition, the antioxidant activities of the extracts were measured by radical scavenging activity of antioxidants against the free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH). The antioxidant activities of the extracts of V. pseudo-negundo seed were higher than those of the standard synthetic antioxidants, BHT, ascorbic acid and gallic acid.

کلیدواژه‌ها

Vitex pseudo-negundo؛ GC/MS؛ Hexadecanoic acid؛ Elemol؛ Antioxidant Activity

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