4-Sulfobenzoic Acid as an Efficient Catalyst for the Preparation of 3,4-dihydropyrimidin-2-(1H)-ones Under Solvent-free Conditions

Journal of Applied Chemical Research

مقاله 3، دوره 13، شماره 1، فروردین 2019، صفحه 36-44   

نوع مقاله: Research Paper

نویسندگان

Ali Oudi؛ Nourallah Hazeri^* ؛ Maryam Fatahpour

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

چکیده

In this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones have
been developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate,
aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a new, effective,
inexpensive, and available bronsted acid. Avoidance of toxic and dangerous solvents, easy isolation
of products without the need of column chromatography, high yields, and short reaction time are
some important features of the present method.

کلیدواژه‌ها

3؛ 4-dihydropyrimidin-2-(1H)-one؛ 4-sulfobenzoic acid؛ One-pot؛ Solvent-free