Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions

Iranian Journal of Catalysis

مقاله 5، دوره 6، شماره 2، شهریور 2016، صفحه 127-131   

نوع مقاله: Articles

نویسندگان

Farzaneh Mohamad Pour¹؛ Malek Taher Maghsoodlou^{* 1}؛ Reza Heydari¹؛ Mojtaba Lashkari²

¹Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran.

²Faculty of Science, Velayat University, Iranshahr, Iran.

چکیده

Oxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of
3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is studied. The most remarkable benefits of this synthetic method include the green methodology, an eco-friendly, inexpensive and non-toxic catalyst, solvent-free conditions, the availability of materials, and a simple operational procedure with no column chromatographic separation. The products were characterized by melting points, IR and 1H NMR spectroscopy.

کلیدواژه‌ها

Oxalic acid.2H2O؛ Green methodology؛ Biginelli reaction؛ 3؛ 4-Dihydropyrimidinone

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