Effect of Cichorium intybus L. extracts and Kelussia oderatassima Mozaff. essential oil on toxic of organophosphouros insecticides in RAT

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 3، دوره 1، شماره 2، آبان 2010، صفحه 30-35   

نوع مقاله: Original article

نویسندگان

Abdollah Ghasemi Pirbalouti^{* 1}؛ Ali Shahvali²؛ Firozeh Saghaee³؛ Shahrzad Azizi⁴؛ Behzad Hamedi⁵؛ Lohraseb Shahgholian³

¹Assistant Professor, Research Centre of Medicinal Plants & Ethno-veterinary, Islamic Azad University-Shahrekord Branch, Shahrekord, Iran, PoBox:166

²DVM, Veterinary Medicine Faculty, Islamic Azad University-Shahrekord Branch, Shahrekord, Iran;

³Assistant Professor, Veterinary Medicine Faculty, Islamic Azad University-Shahrekord Branch, Shahrekord Iran;

⁴MS.c. Student of Medicinal Plant, Islamic Azad University-Shahrekord Branch, Shahrekord Iran;

⁵Research Centre of Medicinal Plants & Ethno-veterinary, Islamic Azad University-Shahrekord Branch, Shahrekord, Iran

چکیده

Background & Aim: Organophosphates are frequently used as insecticides in households, in agricultural areas and veterinary, thus posing a risk for accidental dermal exposure or through inhalation. Acute organophosphate poisoning causes thousands of human mortalities each year in developing countries.   Material & Methods: This study carried out to study an antitoxic effect of endemic Iranian medicinal plants agent against organophosphorus on rats. In order, anti-toxic effects of Cichorium intybus L. root ethanol extract and Kelussia oderatassima Mozaff. leaves essential oil on liver and kidney rat. This is an experimental study in 18 Wistar rats were randomly into 6 groups. After 24 hr fasting, normal saline was given to the first group, two and three groups received 200 and 400 mg/kg Cichorium intybus extract, four and five groups received 200 and 400 mg/kg Kelussia oderatassima essential oil and six groups received standard drug (Phenobarbital). Results & Discussion:  The histopathological observation indicated that the lowest necrosis in kidney was group received 200 mg/kg Kelussia oderatassima essential oil and highest necrosis in kidney was groups received 200 and 400 mg/kg Cichorium intybus extract and standard drug. The histopathological observation indicated that standard drug and groups received 400 mg/kg Cichorium intybus extract and 200 mg/kg Kelussia oderatassima essential oil may protect liver against acute hepatotoxicity induced by Organophosphate insecticide. Also the highest of increased weight rats revealed group received 200 mg/kg Kelussia oderatassima essential oil. Conclusion: The results show that Kelussia oderatassima essential oil an antitoxic effect against organophosphrus on at.

کلیدواژه‌ها

Medicinal plants؛ Organophosphates؛ Toxicology؛ Kelussia oderatassima

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