The effect of Hypericum scabrum on the hematologic factors, body weight and temperature in mice

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 4، دوره 1، شماره 4، خرداد 2011، صفحه 25-31   

نوع مقاله: Original article

نویسندگان

Abdollah Ghasemi Pirbalouti^{* 1}؛ Mohsen Jafarian Dehkordi²؛ Rahman Poorhakim Davoodi²؛ Behzad Hamedi¹؛ Mohammad Rabie¹

¹Research Center of Medicinal Plants and Ethno-veterinary, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;

²Department of Clinical Pathology, Faculty of Veterinary, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;

چکیده

Background & Aim: Vast variety of plants in various regions of the country and lack of enough information on their chemical combinations, sometimes lead to triggering poisoning and unsatisfied complications. Regarding to fabulous herbal characteristics of Hypricum, many research about poisoning and side effects of high concentrations of H. scabrum have not taken place until now. Therefore regarding to above mentioned issues, current study has done due to evaluating poisoning effects of H. scabrum on behavioral properties of mice.
Experimental: In an experimental study, first H. scabrum collected from Sabz-e-Kooh mountains, Chaharmahal va Bakhtiari province. There were five 4 mice-group that has taken 100, 250, 500 and 1000 mg/kg H. scabrum extract and one group didn’t get anything. Lastly, after 24 hours various hematologic, weight, and temperature characteristics have been evaluated. Also, like the past method these properties were evaluated for 14 days after taking extracts.
Results & Discussion: In pathologic evaluation of kidney and liver, no obvious difference was seen. In statistical analysis of the results about HCT, Hb, RBC, Mono, MCV, Band, MCH, MCHC and PH no significant differences obtained between case groups and control group. About WBC, neutrophils and eosinophils count significant difference was gathered (p<0.05), that the reason was physiologic stress due to high dosage of the drug; because band cells (immature neutrophils), marker of infection and bone marrow response, has not decreased.
Industrial and practical recommendations: Totally in current study it seems that H. scabrum extract, in none of the concentration used, have poisoning effect and just can lead to stress profile in subjects. But regarding the body weights after 2 weeks of experiment, it can be concluded probably the plant was lead to weight gain. Entirely H. scabrum had not any harmful effects but pathologic ones on liver in high concentrations.

کلیدواژه‌ها

Hypericum scabrum L؛ Body weight؛ Body temperature؛ Hematologic factors؛ Toxicology

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