Effect of ellagic acid on oxidative stress duo to brain ischemia/hypoperfusion in male rat

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 1، دوره 5، شماره 1، تیر 2014، صفحه 1-6   

نوع مقاله: Original article

نویسندگان

Maryam Rafieirad^{* 1}؛ Khadijeh Ghasemzadeh-Dehkordi²

¹Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran

²Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran

چکیده

Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral administration of ellagic acid (50 mg/kg) on brain oxidative stress indices after permanent bilateral common carotid artery occlusion or ischemia/hypoperfusion in male adult rats. Experimental: A number of 30 rats were divided into test and control groups. To make animal model of permanent cerebral hypo perfusion/ischemia, carotid arteries were ligatured as upper and lower and cut bilaterally. Rat brain tissue was extracted to separate hippocampus and measure malondialdehyde, and thiol (-Sh) groups. Results & Discussion: Our results indicated that malondialdehyde and thiol in ischemia group has significantly increased (p < 0.001) than to control group. In addition, the rate of malondialdehyde and thiol in ischemia group receiving the ellagic acid has significantly decreased (p < 0.001), than to ischemia group. Recommended applications/industries: Ellagic acid possibly with powerful antioxidant properties, can improve the effect of ischemia such as production of free radicals.

کلیدواژه‌ها

Brain ischemia؛ Ellagic acid؛ Malondialdehyde؛ Oxidative stress؛ Thiol

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