Nephroprotective activity of Mammea africana stem bark against paracetamol induced kidney injury

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 8، دوره 5، شماره 1، تیر 2014، صفحه 45-54   

نوع مقاله: Original article

نویسندگان

Jude Efiom Okokon^* ؛ Bawo Michael

Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

چکیده

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidney function parameters such as serum urea and creatinine, electrolyes (K⁺, Na⁺, Cl^- and HCO^-₃),  antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA) and histopathological study of the liver. Results & Discussion: The administration of the stembark extract caused significant dose-dependent reduction of high levels of serum creatinine and urea. The electrolytes levels were not affected. Histology of the kidney sections of extract and silymarin- treated animals showed reductions in the pathological features compared to the paracetamol- treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked nephroprotective effect of the stembark extract of M. africana Recommended applications/industries: The results show that the stembark extract of Mammea africana has nephroprotective potential which may be due to its antioxidant effect activity.

کلیدواژه‌ها

Mammea africana؛ Nephroprotective؛ Antioxidant؛ Kidney

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