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Phytochemical study and anti-inflammatory activity of the roots of Mangifera indica L. in lipopolysaccharide (LPS)-stimulated peritoneal macrophages | ||
Trends in Phytochemical Research | ||
مقاله 3، دوره 3، شماره 1، خرداد 2019، صفحه 53-60 اصل مقاله (563.44 K) | ||
نوع مقاله: Original Article | ||
نویسندگان | ||
Yolande Djouatsa Nangue1؛ Eulogio José Llorent-Martínez2؛ Maria Luisa Fernández-de Córdova2؛ Douglas Alphonse M. Ngangoum3؛ Télesphore Benoit Nguelefack3؛ Anatole Guy Blaise Azebaze1؛ Alain Bertrand Dongmo* 4 | ||
1Department of Chemistry, Faculty of Sciences, P.O. Box 24157, University of Douala, Cameroon | ||
2Department of Physical and Analytical Chemistry, University of Jaén, Campus Las Lagunillas S/N, E-23071 Jaén, Spain | ||
3Department of Animal Biology, Faculty of Sciences, P.O. Box 67, University of Dschang, Cameroon | ||
4Department of Animal Biology and Physiology, Faculty of Sciences, P.O. Box 24157, University of Douala, Cameroon | ||
چکیده | ||
This study deals with the identification of secondary metabolites of methanol extract of the roots of Mangifera indica L and the assessment of plant in vitro anti-inflammatory activity. High-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn) using the negative ion mode was performed to establish the chromatographic fingerprint and identify various chemical components of the plant extract. The anti-inflammatory effect of the MeOH extract (3, 30 and 300 μg/mL) was assessed through cell viability and nitric oxide (NO) production on non-stimulated and LPS-stimulated peritoneal macrophages. Phytochemical analysis indicated the presence of a number of phenolic compounds where galloyl derivatives, mangiferin and its derivatives were the major constituents. The methanol extract exhibited significant concentration-dependent inhibitory effect on NO production, both on stimulated and non-stimulated macrophages. The concentration 300 μg/mL showed significant cell toxicity. The methanol extract of Mangifera indica is rich in phenolic compounds and possesses potent in vitro anti-inflammatory activity, but its higher concentrations are cytotoxic. | ||
کلیدواژهها | ||
Anti-inflammatory؛ Cytotoxicity؛ Mangifera indica؛ Nitric oxide؛ Phenolic compounds | ||
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