Prevalence of anal HPV in women with cervical neoplastic and paraneoplastic lesions from Bogotá, Colombia.

International Journal of Molecular and Clinical Microbiology

مقاله 1، دوره 9، شماره 1، شهریور 2019، صفحه 1074-1081   

نوع مقاله: Research Article

نویسندگان

Hernan Vargas^{* 1}؛ Jenny Paola Sanchez²؛ Alejandra Obando³؛ Viviana Barbosa⁴؛ Sandra Gomez⁴؛ Patricia Arce³؛ Esperanza Teuzaba⁵؛ Sonia Salamanca⁶؛ Carlos Golijow⁷

¹Profesional Especializado Laboratorio de Salud Publica Secretaria Distrital de Salud

²Laboratorio de Salud Publica Secretaria Distrital de Salud

³Laboratorio de Salud Publica. Secretaria Distrital de Salud

⁴Laboratorio de Salud Publica, Secretaria Distrital de Salud

⁵Laboratorio de Anatomìa y patología, Patolab RX Ltda

⁶Ginesalud IPS

⁷Institute of Veterinary Genetics "Ing. Fernando Dulout "(IGEVET, CONICET-UNLP, Argentina).

چکیده

The incidence of anal squamous cell carcinoma has increased in the last few decades. Anal cancer has been associated with persistent infection with high-risk human papillomavirus (HR-HPV) types. However, only a few data reflect the status of anal HPV infection in women with cervical neoplastic and paraneoplastic lesions. The objective of the present study was to investigate the distribution of HPV genotypes and abnormal anal cytology in sexually active women with cervical disease from Bogota, Colombia. Methods: We therefore performed anal cytology for type-specific HPV identification in 134 anal samples of sexually active women from Bogota, Colombia, presenting cervical disease; using a commercial molecular technique (Linear Array®; Roche, Molecular Systems, USA). Results: Results of anal cytology were normal in 93.3% of samples, while the remaining 5.2% was classified as atypical squamous cells of undetermined significance (ASC-US), 0.75% high-grade anal intraepithelial neoplasia (LGAIN-II/III,) and 0.75% low-grade AIN ( (HGAIN-I). The analysis for viral infection in the 134 anal samples showed HPV in 61.5% of the studied population. In general, higher HPV infection values were seen in more compromised anal lesions. The most prevalent viral genotypes were HPV-16 (27.7%), -6 (25.30%), -58 (15.70%), -18 (9.60%) and -53 (9.60%). Multiple infections were more common than single ones, and HR-HPV genotypes were present in 69.80% of positive samples. Conclusion: Updating data concerning the distribution of genotypes that infect the anal mucosa may contribute to the implementation of strategies focused on reducing the rate of anal cancer morbidity and mortality.

کلیدواژه‌ها

Anal Cancer؛ Human Papillomavirus؛ Prevalence HPV؛ HPV Epidemiology؛ Female