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Fallah, Zari, Nasr Isfahani, Hossein, Tajbakhsh, Mahmood, Mohseni, Mojtaba, Tashakkorian, Hamed, Amouei, Abdoliman, Zabihi, Ebrahim, Abedian, Zeinab. (1398). Antibacterial and Cytotoxicity Effects of TiO2-Grafted Cellulose Nanocomposite. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13(3), 87-96.
Zari Fallah; Hossein Nasr Isfahani; Mahmood Tajbakhsh; Mojtaba Mohseni; Hamed Tashakkorian; Abdoliman Amouei; Ebrahim Zabihi; Zeinab Abedian. "Antibacterial and Cytotoxicity Effects of TiO2-Grafted Cellulose Nanocomposite". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13, 3, 1398, 87-96.
Fallah, Zari, Nasr Isfahani, Hossein, Tajbakhsh, Mahmood, Mohseni, Mojtaba, Tashakkorian, Hamed, Amouei, Abdoliman, Zabihi, Ebrahim, Abedian, Zeinab. (1398). 'Antibacterial and Cytotoxicity Effects of TiO2-Grafted Cellulose Nanocomposite', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13(3), pp. 87-96.
Fallah, Zari, Nasr Isfahani, Hossein, Tajbakhsh, Mahmood, Mohseni, Mojtaba, Tashakkorian, Hamed, Amouei, Abdoliman, Zabihi, Ebrahim, Abedian, Zeinab. Antibacterial and Cytotoxicity Effects of TiO2-Grafted Cellulose Nanocomposite. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1398; 13(3): 87-96.

Antibacterial and Cytotoxicity Effects of TiO2-Grafted Cellulose Nanocomposite

Journal of Applied Chemical Research
مقاله 8، دوره 13، شماره 3، مهر 2019، صفحه 87-96    اصل مقاله (481.67 K)
نوع مقاله: Research Paper
نویسندگان
Zari Fallah1؛ Hossein Nasr Isfahani* 1؛ Mahmood Tajbakhsh* 2؛ Mojtaba Mohseni3؛ Hamed Tashakkorian4؛ Abdoliman Amouei5؛ Ebrahim Zabihi6؛ Zeinab Abedian4
1School of Chemistry, Shahrood University of Technology, Shahrood, Iran
2Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
3School of Molecular and Cell Biology, University of Mazandaran, Babolsar, Iran
4Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5Environmental Health Engineering Department, Babol University of Medical Sciences, Babol, Iran
6Department of Pharmacology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
چکیده
TiO2-grafted cellulose bio-nanocomposite (Cell.Com) was successfully prepared by combining modified cellulose and TiO2 nanoparticles via copper-catalyzed alkyne-azide click reaction. The antibacterial and cytotoxicity effects of Cell.Com containing cellulose, triazole ring and TiO2 moieties are reported in this work. The antibacterial activity of Cell.Com was investigated against gram positive (S. aureus and B. subtilis) and gram negative (E. coli and P. aeruginosa) bacteria. The antibacterial results indicate that the Cell.Com exhibits a wide range of antibacterial activity against both gram positive and gram negative bacteria which is due to the presence of TiO2 and triazole ring moieties in its structure. In addition, the cytotoxicity effect of Cell.Com was studied in vitro on cervical cancer (HeLa), breast carcinoma (MCF-7), sarcoma osteogenic (Saos) and fibroblast cells by MTT assay. The cell viability results show that the Cell. Com diminishes relatively cancer cells growth in a dosage and time dependent way probably through triazole moiety, while no apparent
cytotoxicity effect is observed on the normal fibroblast cells.

کلیدواژه‌ها
nanocomposite؛ Cellulose؛ TiO2؛ Antibacterial؛ Cytotoxicity
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