A new method for the synthesis of novel derivatives of "1,3- diaryl -2-n-azaphenalene and n-acyl-1,3-diaryl-2-N-azephenylene" By using nano catalyst and analyzing antibacterial activity of structures

Journal of Nanoanalysis

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 مرداد 1398

نوع مقاله: Original Research Paper

شناسه دیجیتال (DOI): 10.22034/jna.2019.1871479.1144

نویسندگان

asghar eftekhari¹؛ Naser Forughifar^{* 2}؛ Malak Hekmati³

¹Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

²Department of Chemistry, Tehran North Branch,Islamic Azad University, Tehran, Islamic Republic of Iran

³Pharm. Sci. Branch

چکیده

In this research, synthesized well derivatives of 1,3-diaryl-2-N-azaphenalene and N-acyl-1.3-diaryl-2-N- azaphenalene as a macromolecule in the presence of nanoparticles (Fe3O4 coated with L-Arginine) as a magnetic Nano catalyst in a one-pot reaction of compounds 7.2-Naphthalene diol, aldehydes, ammonium derivatives (ammonium acetate or ammonium hydro phosphates) and solvent (water and alcohol) with high yield and short reaction times, economical and simple workup.
In this study, apart from the innovation in the synthesis of a macromolecule, the antibacterial activity of these compounds was evaluated for the first time
The reaction was doe under very moderate conditions at room temperature.
The chemical structures of all synthesized compounds were determined using infrared, 1H NMR and 13C NMR spectroscopies.
After the production of nanoparticles, the structure of the obtained nanoparticles was characterized via Fourier transform infrared spectroscopy (IR) and field emission scanning electron microscopy (FE-SEM). The results demonstrated that the average size of the synthesized magnetite nanoparticles is about 21 nm.
The heterogeneous catalyst used was easily separated magnetically and reused without any significant loss of catalytic activity and magnetism.
Eventually, antibacterial activity of the synthesized compounds was investigated by Escherichia coli (ATCC: 25922) and Pseudomonas aeruginosa (ATCC: 27853) as gram negative bacteria, Staphylococcus epidermidis (ATCC: 14990) and Staphylococcus aureus (ATCC: 29213) as gram positive bacteria. Some of these products exhibit significant antibacterial activity.

کلیدواژه‌ها

Multicomponent؛ Nanocatalysts؛ One-pot؛ Azaphenalene؛ antibacterial activity