Effect of Electrical Potential on the Morphology of Polyvinyl Alcohol/ Sodium Alginate Electrospun Nanofibers, Containing Herbal Extracts of Calendula Officinalis for Using in Biomedical Applications

Journal of Modern Processes in Manufacturing and Production

مقاله 4، دوره 9، شماره 2، مرداد 2020، صفحه 43-56   

نوع مقاله: Research Paper

نویسندگان

Seyed Rasoul Tahami¹؛ Nahid Hasanzadeh Nemati^{* 2}؛ Hamid Keshvari³؛ Mohammad Taghi Khorasani⁴

¹Department of Biomedical engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

²Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

³Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran

⁴Department of Biomaterial, Iran Polymer and Petrochemical Institute, Tehran, Iran

چکیده

This study aimed to investigate the effect of electrical potential on the morphology of Polyvinyl Alcohol/Sodium Alginate electrospun nanofibers, containing herbal extracts of Calendula Officinalis. For this purpose, Poly Vinyl Alcohol (PVA)/ Sodium Alginate (SAlg) nanofibers were prepared using the electrospinning method in aqueous solutions with PVA (8% w / v)/SAlg (2% w / v) blended system in a volume ratio of 80/20. Then Calendula officinalis extract (10% w / v)in a volume ratio of 10% of PVA/SAlg blended system added. Applying potentials were 5, 10, 15, and 20 kV. The electrospun fibers were characterized by scanning electron microscopy (SEM). The results show that all the produced mats had high-porosity and high-surface to volume ratio of electrospun fibers. In all applied potentials, the diameter of the nanofibers containing Calendula was more than the Calendula-free Nanofibers. On the other hand, the diameters of the Nanofibers in each sample decreased with enhancing the potential. Without significant changes in mat morphology, PVA/SAlg electrospun nanofibers diameter including the Calendula could be controlled with electrical potential in electrospinning. The results could be used in antibacterial meshes, wound dressings, drug delivery, and tissue engineering applications.

کلیدواژه‌ها

Calendula Officinalis؛ Electrospinning؛ Nanofibers؛ Polyvinyl Alcohol؛ Sodium Alginate

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