اخبار و اعلانات

 آمار

تعداد نشریات418
تعداد شماره‌ها10,005
تعداد مقالات83,622
تعداد مشاهده مقاله78,340,942
تعداد دریافت فایل اصل مقاله55,384,192
zivari fard, maryam, sharifi, majid, shojaei, arian, Rezayat, Seyed Mahdi, mousavi, seyyedeh elaheh, Falahati, Mojtaba. (1399). The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, (), -. doi: 10.22034/jna.2020.1893038.1188
maryam zivari fard; majid sharifi; arian shojaei; Seyed Mahdi Rezayat; seyyedeh elaheh mousavi; Mojtaba Falahati. "The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, , , 1399, -. doi: 10.22034/jna.2020.1893038.1188
zivari fard, maryam, sharifi, majid, shojaei, arian, Rezayat, Seyed Mahdi, mousavi, seyyedeh elaheh, Falahati, Mojtaba. (1399). 'The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, (), pp. -. doi: 10.22034/jna.2020.1893038.1188
zivari fard, maryam, sharifi, majid, shojaei, arian, Rezayat, Seyed Mahdi, mousavi, seyyedeh elaheh, Falahati, Mojtaba. The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1399; (): -. doi: 10.22034/jna.2020.1893038.1188

The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte

Journal of Nanoanalysis
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 13 مرداد 1399
نوع مقاله: Original Research Paper
شناسه دیجیتال (DOI): 10.22034/jna.2020.1893038.1188
نویسندگان
maryam zivari fard1؛ majid sharifi2؛ arian shojaei3؛ Seyed Mahdi Rezayat4؛ seyyedeh elaheh mousavi* 1؛ Mojtaba Falahati5
1Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Department of Pharmacology,School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran;
چکیده
Palladium nanoparticles (Pd-NPs) have various applications in industries, such as: Biomedicine, Sewage treatment, Electronics, and Catalytic processes. Different studies on NP have shown that they have negative impacts on different cell categories in vitro. Despite extensive considerations, the molecular mechanism of Pd-NPs toxicity has remained elusive thus far. Therefore, in this paper, we investigated the toxicity of Pd-NPs by evaluating their effects on human lymphocyte. Blood lymphocyte cells were initially isolated by ficoll solution and were exposed to Pd-NPs and Pd (II) ions. Then, we examined oxidative stress, cell cycle and apoptosis employing flow cytometry. We found the NPs administration suppressed cell growth which in turn resulted in cell apoptosis. Also, cell cycle stopped at sub G1 phase, resulting in DNA damage as well as profound ROS increase. Our results showed that Pd-NPs treatment for 24 hours led to apoptosis, oxidative stress, as well as cell cycle blockage. It is notable that Pd (II) ions induced more severe toxicity. Our findings provide valuable insights on Pd-NPs toxicity.
کلیدواژه‌ها
Apoptosis؛ Cell Cycle؛ ROS؛ Human Lymphocyte؛ Nano Pd
آمار
تعداد مشاهده مقاله: 640


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب