Potential of magnetite nanoparticles with biopolymers loaded with gentamicin drug for bone cancer treatment

Journal of Nanoanalysis

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 آبان 1399

نوع مقاله: Original Research Paper

شناسه دیجیتال (DOI): 10.22034/jna.2020.1908273.1229

نویسندگان

Ehsan Nassireslami¹؛ Mehdi Motififard²؛ Bahareh Kamyab Moghadas³؛ Zahra Hami¹؛ Amir Jasemi³؛ Amin Lachiyani⁴؛ Reza Shokrani Foroushani⁵؛ Saeed Saber-Samandari⁶؛ Amirsalar Khandan^{* 6}

¹Toxicology Research Center, AJA University of Medical Sciences, Tehran; Iran

²Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

³Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran

⁴Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

⁵Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

⁶New Technology Research Center, Amirkabir University of Technology, Tehran, Iran

چکیده

Objective (s) Due to the natural bone microstructure, the design and fabrication of porous ceramic scaffold nanocomposite materials coated with thin layer of a natural polymer can provide an ideal scaffold for bone tissue engineering. This study aimed to fabricate multi-component porous magnetic scaffolds by freeze- drying (FD) technique using a gelatin polymer layer coated with a gentamicin drug. Materials and Methods: Magnetic nanoparticles (MNPs) can be manipulated and controlled by an external magnetic field gradient (EMFG) that is inherent in the magnetic field's permeability within human tissues. In the present work, unlike the usual ceramic/polymer composite scaffold, the ceramic components and the magnet were placed together in the reaction medium from the beginning, and bioceramics were replaced in the composite polymer network and then coated with a drug-loaded polymer. To evaluate the morphology of the magnetic scaffold, scanning electron microscopy (SEM) was utilized to evaluate the microstructure and observe the porosity of the porous tissue. Results and Discussion: After analyzing the SEM images, the porosity of the scaffolds was measured, which was similar to the normal bone architecture. Also, the porosity value increased from 55% to 78% with addition of MNPs to the based matrix. Conclusion: The results of this study showed that gentamicin-gelatin-coated on porous ceramic-magnet composite scaffolds could be used in bone tissue engineering and apply for treatment of bone tumors, because of their similarity to the bone structure with good porosity.

کلیدواژه‌ها

Drug Delivery System؛ Magnetization؛ Magnetic Nanoparticles؛ Malignant Tumor