The Electrochemical Sensor for Selective Solid Phase Extraction of Pseudoephedrine Hydrochloride in a Real Sample

Journal of Applied Chemical Research

دوره 15، شماره 1، فروردین 2021، صفحه 8-23   

نوع مقاله: Research Paper

نویسندگان

Morteza Omidinejad¹؛ Mohammad Alimoradi^{* 1}؛ Majid Ramezani¹؛ Sattar Ebrahimi²

¹Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran

²Department of Chemistry, Malayer Branch, Islamic Azad University, Malayer, Iran

چکیده

In  the  current  study,  a  new  technique  was  developed  for  quantification  and  qualification  of pseudoephedrine hydrochloride (PSE) in a real sample, which was based on electrochemical sensors and  molecular  imprinted  polymer  (MIP).  The  carbon  paste  electrode  (CPE)  was  modified  and optimized by a different ratio of MIP. MIP/CPE was used as the extraction and working electrode.
Differential pulse voltammetry (DPV) method was utilized for measurement. The MIP (molecularly imprinted  polymer)  and  NIP  (non-imprinted  polymer)  were  synthesized  by  various  ratios  of functional  monomer  (methacrylic  acid)  and  cross-linker  (ethylene  glycol  dimethacrylate)  and template (pseudoephedrine hydrochloride). Some parameters such as pH, extraction time, MIP/CP ratio,  stirring  rate,  and  concentration  of  sample  were  optimized,  and  under  these  conditions,  the oxidation peak current was proportional to the pseudoephedrine hydrochloride concentration over a range of 10-500 µM with the coefficient  of determination 0.992 (R2). The limit of detection (LOD)
was found about 0.274 µM and the limit of quantification (LOQ) was located about 0.825 µM. The relative standard deviation (RSD) was about 1.17%. The results indicated that the modified electrode had a specific ability in selective extraction of pseudoephedrine hydrochloride.

کلیدواژه‌ها

Molecular imprinted polymer؛ Carbon paste modified electrode؛ Pseudoephedrine hydrochloride؛ Voltammetric sensor

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