Investigation of Antimicrobial and Genotoxic Effects of Fe2O3, NiO and CoO NPs Synthesized by Green Synthesis

Journal of Nanoanalysis

دوره 7، شماره 3، آذر 2020، صفحه 216-224   

نوع مقاله: Original Research Paper

شناسه دیجیتال (DOI): 10.22034/jna.2020.680096

نویسندگان

Hayrunnisa Nadaroglu^{* 1}؛ Azize Alaylı²؛ Selçuk Çeker³؛ Hatice Ogutcu⁴؛ Guleray Agar⁵

¹Ataturk University, Erzurum Vocational College

²2 Department of Nano-Science and Nano-Engineering, Institute of Science and Technology, Ataturk University, 25240 Erzurum, Turkey 3 Department of Nursing, Faculty of Health Sciences, Sakarya University of Applied Sciences, 54187, Sakarya, Turkey

³Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Agri İbrahim Cecen University, 04000, Agrı, Turkey

⁴Ahi Evran University, Faculty of Agriculture, Department of Field Corps, 40200 Kırsehir, Turkey

⁵Department of Biology, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey

چکیده

It is seen that metal nanoparticles are used in many areas due to their antimicrobial
effects. For this reason, our study focused on the production of a-Fe2O3, NiO
and CoO NPs of golden nanoparticles, which are easily obtained with the use of
Erzincan grape extract, safe to use, environmentally friendly and cost-effective.
Metal ions synthesized by the green synthesis method were characterized using
the Scanning Electron Microscope (SEM) analysis. From the SEM diagrams of
the synthesized nanoparticles, it was determined that the nanoparticles were
approximately 5 to 65 nm in size. Both antimicrobial, genotoxicity and cytotoxicity effects were investigated to determine the rates at which nanoparticles can be used as biosafe. Synthesized a-Fe2O3, NiO and CoO NPs showed excellent antibacterial properties on pathogen bacteria against human. In addition, it was determined that a-Fe2O3, NiO and CoO M-NPs showed genotoxic properties in parallel with increasing concentrations. This study, as far as we know, is the first report on microbial a-Fe2O3, NiO and CoO NPs and their biological properties synthesized by this statistical approach.

کلیدواژه‌ها

a-Fe2O3؛ NiO and CoO NPs؛ Green synthesis؛ Antimicrobial activity؛ Genotoxic effect؛ Pathogen microorganisms