One-pot Synthesis of Xanthene Derivatives as Potential Antiviral and Anti-inflammatory Agents using Nano-SnO2 as an Efficient Catalyst

Journal of Applied Chemical Research

دوره 15، شماره 2، مرداد 2021، صفحه 46-54   

نوع مقاله: Research Paper

نویسندگان

Bita Baghernejad^* ؛ Mahsa Fiuzat

Department of Chemistry, Payame Noor University, Iran

چکیده

An efficient three-component one-pot synthesis of 1,8-dioxo-octahydroxanthenes from demedone, aldehydes,  in  the  presence  of  a  catalytic  amount  of nano-SnO2 is  described.  The  reactions  were carried  out  at  80^oC  under  EtOH-solvent  media.  The  structures  of  the  compounds  were characterized  by  IR,¹ H-NMR,¹³C-NMR,  and  Mass  spectra  and  by  elemental  analysis.  The advantages  of  the  effective  method  were  good  yields,  short  reaction  times,  simple  work-up,  ecofriendly solvent, and inexpensive and reusable catalyst. The catalyst could be recycled and reused for five times without much loss of its activity.

کلیدواژه‌ها

Xanthene derivatives؛ Multi–component reaction؛ One-pot؛ Nano-SnO2

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