A review on hepatoprotective effects of Nigella sativa L.

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 7، دوره 12، شماره 1، مرداد 2021، صفحه 49-54   

نوع مقاله: Review article

شناسه دیجیتال (DOI): 10.30495/medherb.2021.681959

نویسندگان

Mehrdad Ostadpoor¹؛ Majid Gholami-Ahangaran^{* 2}

¹Graduated of Veterinary Medicine Faculty, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

²Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

چکیده

Background & Aim:Nigella sativa L. (Black seeds) which is a member of the Ranunculaceae family, grows in Southwestern Asia, Europe, and Northern Africa. The use of N. Sativa seeds and oil in traditional remedies goes back more than 2000 years, and the herb is described as ‘the Melanthion’ by hippocrates and dioscorides.
Experimental: In the current literature review, key words including N. Sativa, thymoquinone, black seeds, toxicity, protection of hepatocellular were searched in scientific websites such as Science Direct, PubMed, Google Scholar etc. to compile the protective effects of N. Sativa against hepatocellular damage.
Results: Many active components of N. Sativa have been identified, including thymoquinone, dithymoquinone, thymohydroquinone, nigellone, melanthin, nigilline, nigelamine, damascenone, p -cymene and pinene. N. Sativa is a medicinal plant with antifungal, anti-viral, anti-bacterial, anti-parasite, anti-oxidant, analgesic, antipyretic, anti-tussive, and anti-inflammatory properties. Thymoquinone could prevent many disorders such as neurobehavioral kidney and liver disorders. N. Sativa was also found to be able to relieve the symptoms of patients with several diseases, such as hypertension, dyslipidemia, metabolic syndrome, diabetes and natural and chemical toxicities.
Recommended applications/industries: According to literature,N. Sativa treatment will decrease the elevated lipid peroxidation, liver enzyme levels and increase antioxidant enzyme levels. N. Sativa administration can also protect hepatic tissue from deleterious effects of toxic metals.

کلیدواژه‌ها

Black seeds؛ Hepatoprotective؛ Nigella sativa؛ Thymoquinone؛ Toxicity

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