In-vitro Antibacterial and Antifungal Screening of Newly Synthesized Trifluoromethylated N-Heterocyclic ketenimines and 1-aza butadiene Derivatives

Journal of Chemical Health Risks

دوره 13، شماره 1، خرداد 2023، صفحه 57-64   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2021.1926711.1280

نویسندگان

Rosa Edris Ameri¹؛ Bita Mohtat^{* 2}؛ Eskandar Alipour¹؛ Nahid Rahimifard³؛ Behrooz Mirza²

¹Department of Chemistry, North Tehran Branch, Islamic Azad University, Iran

²Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

³Food and Drug Control Laboratories (FDCL), Ministry of health and medical Education (MOH), Sarv Saadat Laboratory,Tehran, Iran

چکیده

In our previous work, some trifluoromethylated ketenimines and 1-aza butadienes derivatives from N-H heterocyclic compounds were synthesized, and their characteristics were confirmed by their spectroscopic data as introduced. In this research, the antifungal and antibacterial effects of newly synthesized compounds were evaluated. The antibacterial activity of compounds was studied against Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922, and Pseudomonas aeruginosa ATCC9027. Furthermore, their antifungal activity was monitored against Candida albicans ATCC10231. Disk Diffusion Agar test and minimum inhibitory concentration (MIC) methods were used as per the National Committee for Clinical Laboratory Standards (NCCLS) recommendations. The results showed that the ketenimines derivatives from 2-pyridinone and 4- quinazolinone have considerable antibacterial activity against Staphylococcus aureus and Escherichia coli standard strains. Trifluoromethylated ketenimines and 1-aza butadiene derivatives have no antibacterial effect on P. aeruginosa strain. Moreover, the trimethylated ketenimines and 1-aza butadienes derivated from 4-quinazolinone showed acceptable antifungal activity against Candida albicans.

کلیدواژه‌ها

Antibacterial activity؛ Antifungal screening؛ Trifluoromethylated ketenimines؛ Trifluoromethylated 1-aza butadienes؛ Disk Diffusion Agar test؛ Minimum inhibitory

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