Carvacrol Attenuates Disrupted Lipid Profile Induced by Organophosphates in Male Wistar Rat: a Comparative Toxicity

Journal of Chemical Health Risks

مقاله 14، دوره 11، Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases، دی 2021، صفحه 121-128   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2021.1925415.1277

نویسندگان

Ali Salari¹؛ Kambiz Roshanaei²؛ Bahram Rasoulian³؛ Javad Khalili Fard^{* 4، 5}

¹Department of Physiology, Faculty of Sciences, Qom Branch, Islamic Azad University, Qom, Iran

²Department of Biology, Faculty of Sciences, Qom Branch, Islamic Azad University, Qom, Iran

³Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

⁴Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

⁵Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

چکیده

Many people in agricultural industry are nowadays struggling with protecting their products utilizing pesticides. Pesticides, such as organophosphate (OPE) insecticides, may remain on agricultural products as pesticide residues. Malathion (MTN) is an OPE widely used around the world. Some OPEs, such as parathion (PTN), are more toxic pesticides and have been restricted. Carvacrol (CRL) is a major component of Satureja khuzestanica essential oil, whichexerted protective effects against toxicity of chemicals. OPEs can alter lipid profile. In addition, lipid profile may alter due to certain disorders, such as nephrotic syndrome. The present study aimed to investigate the effects of coadministration of CRL and the effect of these two pesticides on serum acetylcholinesterase (AchE) activity and lipid profile in male wistar rat. Coadministration of CRL and PTN, but not MTN, significantly decreased serum AchE activity in comparison with the group receiving OPE. Serum levels of cholesterol and triglyceride were analyzed after 10 days of administration of the chemicals. Malathion and PTN significantly increased cholesterol and triglyceride. However, administration of CRL modified lipid profile (P < 0.05). It was concluded that CRL could be considered as a drug to treat lipid profile alteration and owing to the beneficial effects as well as inhibition of acetylcholine, it could be considered as a component of OPE pesticide.

کلیدواژه‌ها

Malathion؛ Parathion؛ Carvacrol؛ Cholesterol؛ Triglyceride؛ Rat

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