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Abdulwaliyu, Ibrahim, Okoduwa, Stanley, Arekemase, Shefiat O., Muhammad, Aliyu, Ibrahim, Sani, Onyike, Elewechi. (1400). Effect of Folic Acid and Vitamin-C Administration on Paraoxonase and Arylesterase -1 Activities in Rats intoxicated with Lead. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 11(Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases), 207-220. doi: 10.22034/jchr.2021.1936171.1365
Ibrahim Abdulwaliyu; Stanley I.R. Okoduwa; Shefiat O. Arekemase; Aliyu Muhammad; Sani Ibrahim; Elewechi Onyike. "Effect of Folic Acid and Vitamin-C Administration on Paraoxonase and Arylesterase -1 Activities in Rats intoxicated with Lead". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 11, Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases, 1400, 207-220. doi: 10.22034/jchr.2021.1936171.1365
Abdulwaliyu, Ibrahim, Okoduwa, Stanley, Arekemase, Shefiat O., Muhammad, Aliyu, Ibrahim, Sani, Onyike, Elewechi. (1400). 'Effect of Folic Acid and Vitamin-C Administration on Paraoxonase and Arylesterase -1 Activities in Rats intoxicated with Lead', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 11(Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases), pp. 207-220. doi: 10.22034/jchr.2021.1936171.1365
Abdulwaliyu, Ibrahim, Okoduwa, Stanley, Arekemase, Shefiat O., Muhammad, Aliyu, Ibrahim, Sani, Onyike, Elewechi. Effect of Folic Acid and Vitamin-C Administration on Paraoxonase and Arylesterase -1 Activities in Rats intoxicated with Lead. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1400; 11(Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases): 207-220. doi: 10.22034/jchr.2021.1936171.1365

Effect of Folic Acid and Vitamin-C Administration on Paraoxonase and Arylesterase -1 Activities in Rats intoxicated with Lead

Journal of Chemical Health Risks
دوره 11، Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases، دی 2021، صفحه 207-220    اصل مقاله (562.79 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/jchr.2021.1936171.1365
نویسندگان
Ibrahim Abdulwaliyu1، 2؛ Stanley I.R. Okoduwa* 3، 4؛ Shefiat O. Arekemase2، 5؛ Aliyu Muhammad2؛ Sani Ibrahim4؛ Elewechi Onyike2
1Department of Basic Research, National Research Institute for Chemical Technology, Zaria, Nigeria
2Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
3Directorate of Research and Development, Nigerian Institute of Leather and Science Technology, Zaria, Nigeria
4Department of Biochemistry, School of Basic Medical Sciences, Babcock University, Ilishan-Remo, Nigeria
5Petrochemical and Allied Department, National Research Institute for Chemical Technology, Zaria, Nigeria
چکیده
Paraoxonase and aryl-esterase-1 (PON-1) in serum of rats intoxicated with lead then administered Folic acid and Vitamin-C was investigated in forty male albino rats (160-190 g) randomly separated into 2 groups of 20 rats each namely: Lead acetate (60 mg kg -1) and normal saline was given to each group for 6 weeks and there after administered Folic acid (500 µg kg -1) and/or Vitamin-C (60 mg kg-1) orally for 4 weeks. Blood sample was obtained at the end from each rat for biochemical assessment. Results obtained indicated significant (p<0.05) reduction in activities of arylesterase (60.51±8.52 U L-1) and paraoxonase (74.95±3.63 U L-1) of non-supplemented, rats intoxicated with lead compared to 121.51±7.34 and 98.19±2.25 U L-1 respectively for the control groups. Similarly, the values of catalase (10.54±0.46 U mg-1) and superoxide dismutase (4.93±0.66 U mg-1), differ significantly (p<0.05) in the non-supplemented group intoxicated with lead as compared to 31.62±0.67 U mg-1, and 28.46±1.54 U mg-1 respectively for the control groups. Malonyldialdehyde level (0.58±0.29 nmol L-1) decreased significantly (p<0.05) in the control group as compared to the 5.21±0.16 nmol L-1 observed in the non-supplemented group intoxicated with lead. Significant (p<0.05) decrease was observed for high-density lipoprotein cholesterol level (41.08±0.48 mg L-1) in the non-supplemented, rats intoxicated with lead as compared to the level (78.67±0.66 mg L-1) noticed in the control group. Findings from this study deduced that sub-chronically lead intoxication may cause cardiovascular diseases as evident in the decreased activities of arylesterase and paraoxonase. However, administration of Folic acid and Vitamin-C to the rats intoxicated with lead improves the catalytic activities of PON-1, and this may mitigate lead-induced cardiovascular disease risk.
کلیدواژه‌ها
Lead؛ Folic acid؛ Vitamin C؛ Paraoxonase/aryl-esterase-1؛ PON-1؛ Lipid profile
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