Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat

Trends in Phytochemical Research

دوره 5، شماره 4، اسفند 2021، صفحه 209-221   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/tpr.2021.1940654.1221

نویسندگان

Md Rafiul Haque^{* 1، 2}؛ Md Afroz Ahmad³؛ Kamran Ashraf⁴؛ Md Habban Akhter⁵؛ Mohammad Jameel⁶؛ Abuzer Ali⁷؛ Wasim Akhtar¹؛ Monika Dhaka⁵؛ Kavita Rana⁸

¹School of Pharmacy, Al-Karim University, Bihar, India

²School of Pharmaceutical Education and Research, Hamdard University, Hamdard Nagar, New Delhi 62, India

³Department of Prmhacology, Integral University, Lucknow (U.P), India

⁴Faculty of Pharmacy, University Teknologi MARA (UITM), Cawangan Selangor, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malasiya

⁵School of Pharmaceutical and population Health information (SoPPHI), DIT University, Dehradun 248009, India

⁶RRIUM, CCRUM Aligarh (UP), India

⁷Department of Pharmacognosy, College of Pharmacy, Taif University, P.O. box 21944, Saudi Arabia

⁸Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida (UP), India

چکیده

In the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, twice a day) treatments reduced body weight, serum triglycerides (TG), total cholesterol (TG), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (ALT) levels (p < 0.001). AA, AA1, and thymol (T) treatments also decreased lipids (TG and TC) levels and increased thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) levels in hepatic tissue (p < 0.001). Moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. These results recommend that arq ajwain has a strong protective effect against NAFLD in HFD induced obese rat models.

کلیدواژه‌ها

Ajwain؛ Insulin؛ Leptin؛ Nonalcoholic fatty liver disease؛ Oxidative stress

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