Fe-Co-V/Zeolite nano composite catalyzed biginelli compounds synthesis and evaluation of their drug cytotoxic activity

Journal of Chemical Reactivity and Synthesis

دوره 10، شماره 1، اردیبهشت 2020، صفحه 17-25   

نوع مقاله: Research Article

نویسندگان

shima Zanganeh Yousef Abadi؛ Mohammad Kazem Mohammadi^* ؛ Haman Tavakkoli

Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

چکیده

An effective one-pot synthesis of bis (dihydropyrimidinonoe) benzenes through Biginelli condensation reaction of terephthalic aldehyde, 1,3-dicarbonyl compounds and (thio) urea under solvent free conditions  is described. Excellent yields of the products and simple work-up are attractive features of this green protocol. Then, the cytotoxic activities of these compounds were evaluated on 5 different human cancerous cell lines (Raji, HeLa, LS-180, SKOV-3 and MCF7). Their cytotoxic study indicated that they possessed a weak to moderate activity. Furthermore, the higher activity of compound 4b bearing sulfur in C₂ position of pyrimidine ring showed the importance of this site for cytotoxic activity of these compounds.

کلیدواژه‌ها

Biginelli reaction؛ nanozeolite؛ terephthalic aldehyde؛ multi-component؛ Cytotoxicity