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A Simple And Efficient Synthesis Of Calcium Channel Blocker Flunarizine | ||
International Journal of Industrial Chemistry | ||
دوره 2، شماره 3، آذر 2011، صفحه 154-157 اصل مقاله (576.62 K) | ||
نوع مقاله: research article | ||
نویسندگان | ||
A. Venkat Narsaiah* 1؛ J. Kranthi Kumar2 | ||
1Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India | ||
2Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India. | ||
چکیده | ||
The T-type calcium channel blocker and anti-ischemic drug, 1- [bis- (4-fluoro phenyl) -methyl] -4-cinnamylpiperazine (1) has been carried out in four steps with an average of 70% yield. This route is very convenient and can be used for large scale preparation of Flunarizine with high yields and at low cost. | ||
کلیدواژهها | ||
AMINATION؛ CALCIUM CHLORIDE BLOCKER؛ CHLORINATION؛ CINNAMYL BROMIDE؛ KETO REDUCTION؛ PIPERAZINE | ||
آمار تعداد مشاهده مقاله: 49 تعداد دریافت فایل اصل مقاله: 75 |