Application of Fe3O4/SiO2/CeO2 nanocomposite, an efficient and magnetic catalyst, to synthesize 2,3-dihydroquinazolin-4(1H)-ones derivatives

Iranian Journal of Catalysis

مقاله 5، دوره 12، شماره 2، شهریور 2022، صفحه 169-180   

نوع مقاله: Articles

شناسه دیجیتال (DOI): 10.30495/ijc.2022.689839

نویسندگان

Elham Mohamadzadeh؛ zinat gordi^*

Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran

چکیده

A supported magnetic nanocomposite as a simple, stable, and efficient catalyst was successfully developed for condensation reaction of aldehydes, ammonium acetate, and isatoic anhydride to prepare 2,3-dihydroquinazolin-4(1H)-one derivatives as essential biologically active heterocyclic compounds. Ethanol as a non-toxic solvent under a reflux condition was utilized in the reactions. The Fe₃O₄/SiO₂/CeO₂ nanocomposite was prepared as a magnetic and novel catalyst. The value of components of the catalyst composite, including Fe₃O₄, SiO₂, and CeO₂, was optimized using experimental design to prepare the best catalyst composite with the highest reaction efficiency. The optimum amounts of Fe₃O₄, SiO₂, and CeO₂ in the catalyst composite were 0.37 g, 0.85 mL, and 1.28 g, respectively. The catalyst structure was characterized by FT-IR spectroscopy, vibrating sample magnetometer, Powder X-ray diffraction, and Transmission electron microscope. A sol-gel procedure was utilized to prepare the catalyst, in which chemical bonds between the catalysis components, leading to a high chemical, mechanical, and thermal stability of the catalyst. Several syntheses of 2,3-dihydroquinazolin-4(1H)-ones derivatives were performed using Fe₃O₄/SiO₂/CeO₂  (0.1 g) in EtOH (10.0 mL) under reflux for 9-19 min with yield in the range of 89-97%. The method displayed various advantages, including high yields, easy workup, low catalyst consumption, high catalyst reusability, low reaction times, and fast and straightforward catalyst separation using a magnet.

کلیدواژه‌ها

2,3-dihydroquinazolin-4(1H)-ones؛ Quinazolin-4(3H)-ones؛ Nanocomposite؛ Magnetic catalyst؛ Fe3O4/SiO2/CeO2؛ Aldehydes

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