Anti-inflammatory potential of aqueous extract and ethyl acetate fractions of Munronia pinnata (Wall) Theob. and the isolated compound, Senecrassidiol

Trends in Phytochemical Research

دوره 6، شماره 3، آذر 2022، صفحه 247-258   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/tpr.2022.1962166.1265

نویسندگان

Swarna Damayanthi Hapuarachchi^{* 1}؛ Thusharie Sugandhika Suresh²؛ Shiroma Hadunnetthi³؛ Wathuge Thamara Priyanthie Sandun Kumari Senarath⁴؛ Chandani Ranasinghe⁵

¹Unit of Pharmacology and Pharmaceutics, Department of Ayurveda, Institute of Indigenous Medicine, University of Colombo, Sri Lanka

²Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka

³Institute of Biochemistry, Molecular Biology, and Biotechnology, University of Colombo, Sri Lanka

⁴Department of Botany, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Lanka

⁵Department of Chemistry, Faculty of Natural Sciences, The Open University of Sri Lanka

چکیده

This study was designed to evaluate in vivo and in vitro anti-inflammatory potential of the different extracts of Munronia pinnata and compare it with the isolated compound, Senecrassidiol by using the carrageenan-induced paw edema animal model in Wistar rats. Munronia pinnata (Wall) Theob (Meliaceae) has been traditionally practiced for hundreds of years by traditional physicians as a home remedy for the treatment of inflammatory conditions in folk medicine in Sri Lanka. The tested ethyl acetate fractions of methanol extract and its isolated compound senecrassidiol exhibited significant anti-inflammatory activity in the tested models. It demonstrated the scientific rationale for the use of an anti-inflammatory agent in folk medicine. The MPaq showed a significant (p < 0.5) inhibition of infiltration of rat peritoneal cells, inhibition of NO production by rat peritoneal cells, and inhibition of membrane stabilization as well as the anti-histamine activity which are the probable anti-inflammatory mechanisms. 

کلیدواژه‌ها

Anti-inflammatory؛ Folk medicine؛ Membrane stabilization؛ Munronia pinnata؛ Senecrassidiol؛ Wistar rats

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