The Influence of Fish Oil Supplementation on the Adverse Effects of Chemotherapy in Patients with Hepatocellular Carcinoma

Journal of Chemical Health Risks

دوره 13، شماره 1، خرداد 2023، صفحه 125-133   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2022.697645

نویسندگان

Radhwan M. Hussein^{* 1}؛ Adil Tawfeeq Mohammed²؛ Duha Mahdi Hussein³؛ Ali Abdulhussain Fadhil⁴؛ Muzahem Shallal Al-Ani⁵؛ Suhail Bayati⁶؛ Ahmed Abbas Sahib⁷

¹College of pharmacy, Ahl Al Bayt University, Kerbala, Iraq

²Department of Pharmacy, Al-Noor University College, Bartella, Iraq

³Department of Medical Laboratory Techniques, Al-Mustaqbal University College, 51001 Hillah, Babylon, Iraq

⁴College of Medical Technology, Medical Lab techniques, Al-Farahidi University, Baghdad, Iraq

⁵Department of Medical Laboratory Technologies, Al-Nisour University College, Baghdad, Iraq

⁶Al-Hadi University College, Baghdad, 10011, Iraq

⁷Mazaya University College, Baghdad, Iraq

چکیده

Chemotherapy is among the most crucial therapeutic options for advanced hepatocellular cancer (HCC). There are side effects associated with chemotherapy drug use in cancer patients. It has been shown in animal models that the consumption of omega-3 fatty acids can be effective in reducing the side effects. The purpose of this study is to assess the impact of fish oil supplementation on the adverse effects of chemotherapy in HCC patients. The present research was conducted as a double-blind clinical trial in Erbil City, Kurdistan region, Iraq between May 12, 2020, and December 16, 2021. After an interview, 28 HCC patients who volunteered and were receiving chemotherapy were randomly assigned to the experimental group and another 28 to the control group. The control group was given a placebo for six weeks whereas the experimental group received 3 g of omega-3 fatty acids. Following the initial collection of information for both groups, data on the side effects of chemotherapy were gathered at the start, the fourth, and the sixth weeks following the intervention. The data were examined using the independent sample t-tests, descriptive statistics, chi-square, and Cochran's Q-test. According to the study's findings, the patients in the experimental group had less nausea with passing time, and this difference was statistically significant (p<0.05). It is possible to draw the conclusion that taking fish oil supplements while receiving chemotherapy for HCC may be advantageous because it may lessen some of the negative effects of the treatment.

کلیدواژه‌ها

Chemotherapy؛ Fatty acids supplementation؛ Hepatocellular carcinoma؛ Pathology

مراجع

1. Lewandowska A., Rudzki G., Lewandowski T., Próchnicki M., Rudzki S., Laskowska B., Brudniak J., 2020. Quality of life of cancer patients treated with chemotherapy. International Journal of Environmental Research and Public Health. 17(19), 6938.
2. Redd W.H., Burish T.G., Andrykowski M.A., 2021. Aversive conditioning and cancer chemotherapy, in Cancer, Nutrition, and Eating Behavior, Routledge. pp. 117–132.
3. Morrow G.R., Black P.M., 2021. Anticipatory nausea and vomiting side effects experienced by cancer patients undergoing chemotherapy treatment, in Effect of Cancer on Quality of Life, CRC Press. pp. 251–268.
4. Burish T.G., Redd W.H., Carey M.P., 2021. Conditioned nausea and vomiting in cancer chemotherapy: Treatment approaches, in Cancer, Nutrition, and Eating Behavior, Routledge. pp. 205–224.
5. El-Agamy S.E., Abdel-Aziz A.K., Esmat A., Azab S.S., 2019. Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain. Cancer Chemotherapy and Pharmacology. 84(1), 1–14.
6. Schagen S.B., Tsvetkov A.S., Compter A., Wefel J.S., 2022. Cognitive adverse effects of chemotherapy and immunotherapy: are interventions within reach? Nature Reviews Neurology. 18(3), 173–185.
7. Lee H.S., Jo H.H., Kim K.W., Shin B.-S., Kang H.G., 2022. Atypical Cognitive Impairment and Recovery in Two Colorectal Cancer Patients. Tomography. 8(3), 1503–1508.
8. Graham K., Unger E., 2018. Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment. International Journal of Nanomedicine. 13, 6049.
9. Galluzzi L., Pedro B.-S., Manuel J., Demaria S., Formenti S.C., Kroemer G., 2017. Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nature Reviews Clinical Oncology. 14(4), 247–258.
10. Najafi S., Haghighat S., Raji Lahiji M., RazmPoosh E., Chamari M., Abdollahi R., Asgari M., Zarrati M., 2019. Randomized study of the effect of dietary counseling during adjuvant chemotherapy on chemotherapy induced nausea and vomiting, and quality of life in patients with breast cancer. Nutrition and Cancer. 71(4), 575–584.
11. Miller M., Kearney N., 2004. Chemotherapy-related nausea and vomiting–past reflections, present practice and future management. European Journal of Cancer Care. 13(1), 71–81.
12. Mossanen M., Gore J.L., 2014. The burden of bladder cancer care: direct and indirect costs. Current Opinion in Urology. 24(5), 487–491.
13. Tas D., Uncu D., Sendur M., Koca N., Zengin N., 2014. Acupuncture as a complementary treatment for cancer patients receiving chemotherapy. Asian Pacific Journal of Cancer Prevention. 15(7), 3139-3144.
14. Eghbali M., Yekaninejad M.S., Jalalinia S.F., Samimi M.A., Sa’atchi K., 2016. The effect of auricular acupressure on nausea and vomiting caused by chemotherapy among breast cancer patients. Complementary Therapies in Clinical Practice. 24, 189–194.
15. Sumneangsanor T., Ruchiwit M., Weglicki L., 2021. Non-drug Stress Management for Patients with Cancer: A Systematic Review. The Open Nursing Journal. 15(1), 211-217.
16. Yu J.P., Sun S.P., Sun Z.Q., Ni X.C., Wang J., Li Y., Hu L.J., Li D.Q., 2014. Clinical trial of thalidomide combined with radiotherapy in patients with esophageal cancer. World Journal of Gastroenterology: WJG. 20(17), 5098.
17. Chen Z., Xie H., Hu M., Huang T., Hu Y., Sang N., Zhao Y., 2020. Recent progress in treatment of hepatocellular carcinoma. American Journal of Cancer Research. 10(9), 2993.
18. Schwartzberg L.S., Modiano M.R., Rapoport B.L., Chasen M.R., Gridelli C., Urban L., Poma A., Arora S., Navari R.M., Schnadig I.D., 2015. Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial. The Lancet Oncology. 16(9), 1071–1078.
19. Badowski M.E., 2017. A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics. Cancer Chemotherapy and Pharmacology. 80(3), 441–449.
20. Malach M., Kovalchuk I., Kovalchuk O., 2022. Medical Cannabis in Pediatric Oncology: Friend or Foe? Pharmaceuticals. 15(3), 359.
21. Horigome A., Okubo R., Hamazaki K., Kinoshita T., Katsumata N., Uezono Y., Xiao J.Z., Matsuoka Y.J., 2019. Association between blood omega-3 polyunsaturated fatty acids and the gut microbiota among breast cancer survivors. Beneficial Microbes. 10(7), 751–758.
22. Tabari Shahandasht N., Bolandi M., Rahmati M., Jafarisani M., 2021. A Review of Non-pharmacological Oral Supplements Containing Nutrients and Micronutrients in the Treatment of Osteoarthritis. Journal of Chemical Health Risks.
23. Wei L., Wu Z., Chen Y.Q., 2022. Multi-targeted therapy of cancer by omega-3 fatty acids-an update. Cancer Letters. 526 193–204.
24. Schueren M.A. de van der., 2019. Use and effects of oral nutritional supplements in patients with cancer. Nutrition. 67(68), 110550.
25. Liu Z., Huang P., Law S., Tian H., Leung W., Xu C., 2018. Preventive effect of curcumin against chemotherapy-induced side-effects. Frontiers in Pharmacology. 9, 1374.
26. Alhamadany A.Y.M., Sadek W.S., 2022. Analysis of the Chromosomal Aberrations in Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and Hepatocellular Carcinoma Patients (HCC) in Mosul City, Iraq. NTU Journal of Pure Sciences. 1(2), 48–53.
27. Singh P., 2012. Sample size for experimental studies. J Clin Prev Cardiol. (2), 88–93.
28. Wang S.Y., Zhu W.H., Vargulick S., Lin S.B., Meng Z.Q., 2013. Nausea and vomiting after transcatheter arterial chemoembolization for hepatocellular carcinoma: incidence and risk factor analysis. Asian Pacific Journal of Cancer Prevention. 14(10), 5995–6000.
29. Nitta H., Baba H., Sugimori K., Furuse J., Ohkawa S., Yamamoto K., Minami H., Shimokawa M., Wakabayashi G.O., Aiba K., 2016. Chemotherapy-induced nausea and vomiting in patients with hepatobiliary and pancreatic cancer treated with chemotherapy: A prospective observational study by the CINV study group of Japan. Anticancer Research. 36(4), 1929–1935.
30. Yavuzsen T., Kazaz N., Tanriverdi Ö., Akman T., Davis M.P., 2019. Symptom Management in Gastrointestinal Cancers, in Textbook of Gastrointestinal Oncology, Springer. pp. 669–685.
31. Edmonds K., Hull D., Spencer-Shaw A., Koldenhof J., Chrysou M., Boers-Doets C., Molassiotis A., 2012. Strategies for assessing and managing the adverse events of sorafenib and other targeted therapies in the treatment of renal cell and hepatocellular carcinoma: recommendations from a European nursing task group. European Journal of Oncology Nursing. 16(2), 172–184.
32. Ryan A.M., Power D.G., Daly L., Cushen S.J., Bhuachalla Ē.N., Prado C.M., 2016. Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later. Proceedings of the Nutrition Society. 75(2), 199–211.
33. Huot J.R., Pin F., Bonetto A., 2022. Therapy-Induced Toxicities Associated with the Onset of Cachexia, in The Systemic Effects of Advanced Cancer, Springer. pp. 139–153.
34. Flores-Pérez J.A., Rosa Oliva F. de la, Argenes Y., Meneses-Garcia A., 2019. Nutrition, cancer and personalized medicine. Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics. 157–168.
35. Zhou K., Zhang J.-Y., Yang X.-W., 2020. Progress research on non-drug therapy in cancer-related fatigue. TMR Non-Drug Therapy. 3(4), 192–198.
36. West L., Yin Y., Pierce S.R., Fang Z., Fan Y., Sun W., Tucker K., Staley A., Zhou C., Bae-Jump V., 2020. Docosahexaenoic acid (DHA), an omega-3 fatty acid, inhibits tumor growth and metastatic potential of ovarian cancer. American Journal of Cancer Research. 10(12), 4450.
37. Yekta Z.P., Ebrahimi S.M., Hosseini M., Nasrabadi A.N., Sedighi S., Surmaghi M.-H.S., Madani H., 2012. Ginger as a miracle against chemotherapy-induced vomiting. Iranian Journal of Nursing and Midwifery Research. 17(5), 325.
38. Bruera E., Strasser F., Palmer J.L., Willey J., Calder K., Amyotte G., Baracos V., 2003. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study. Nutrition in Clinical Practice. 18(6), 524–524.
39. Mansara P., Ketkar M., Deshpande R., Chaudhary A., Shinde K., Kaul-Ghanekar R., 2015. Improved antioxidant status by omega-3 fatty acid supplementation in breast cancer patients undergoing chemotherapy: a case series. Journal of Medical Case Reports. 9(1), 1–6.
40. Soni S., Torvund M., Mandal C.C., 2022. Omega-3 fatty acid treatment combined with chemotherapy to prevent toxicity, drug resistance, and metastasis in cancer. Current Drug Targets. 23(6), 574–596.
41. Chen J., Garssen J., Redegeld F., 2021. The efficacy of bortezomib in human multiple myeloma cells is enhanced by combination with omega-3 fatty acids DHA and EPA: Timing is essential. Clinical Nutrition. 40(4), 1942–1953.