Antibacterial activity of Nigerian medicinal plants as panacea for antibiotic resistance: A systematic review

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

دوره 13، شماره 3، اسفند 2022، صفحه 11-23   

نوع مقاله: Review article

شناسه دیجیتال (DOI): 10.30495/medherb.2022.698251

نویسندگان

Adam Mustapha^{* 1}؛ Obi Chidiebere²؛ Fasogbon Ilemobayo Victor³؛ Mshelia Mari Bata²؛ Nuhu Tanko⁴؛ Micheal Nosano Yakubu⁵؛ Zenoh Danjuma Ali⁶؛ Alegbe Sunday David⁷

¹Department of Microbiology, Faculty of Science, University of Maiduguri, Borno State, Nigeria;

²Department of Microbiology, Faculty of Science, Federal University Birnin Kebbi, Kebbi State, Nigeria;

³Department of Biochemistry, Kampala International University Western Campus, Ishaka, Uganda;

⁴Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University Sokoto, Nigeria;

⁵Department of Microbiology, Faculty of Science, Federal University Wukari, Taraba State, Nigeria;

⁶Department of Medical Laboratory Science, Faculty of Health Sciences, Taraba State University Jalingo, Nigeria;

⁷Department of Microbiology, Faculty of Life Science, Ahmadu Bello University Zaria, Nigeria;

چکیده

Background & Aim: Antibiotic resistance is one of the global public health threats facing modern health care system. The development of new effective agents has been challenging. Thus, the interest in the use of medicinal plants for the treatment of bacterial infections has increased. Therefore, the aim of this study was to review Nigerian medicinal plants with antibacterial activity.
Experimental: This study retrieved data from published articles on Nigerian medicinal plants with antibacterial activity. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were adopted. A systematic search of PUBMED CENTRAL was conducted. The included studies were those published in peer-reviewed English language journals between 1^st January 2000 and 31^st December 2020 and reported on the key terms; Nigerian medicinal plants with antibacterial activity. 
Results: The database searches yielded a total of 817 results, and 765 articles were ineligible. After reviewing relevant titles and abstracts, a total of 52 articles on antibacterial were retrieved for full text review. After extensive review of each article, 13 articles were excluded and a total of 39 articles were retained. Furthermore, 4 articles were also removed due to lack of specific compounds stated. Finally, only 35 articles met the inclusion criteria for the assessment of antibacterial activity of Nigerian medicinal plants. The narrative synthesis of the included studies revealed different plants families with broad activities against gram-positive and gram-negative bacteria. Among the bacterial isolates, Staphylococcus aureus was tested more, followed by Escherichia coli and Pseudomonas aeruginosa and the bacteria were subjected to 97 medicinal plants species for antibacterial activity.
Recommended applications/industries: The results from this study reveal that many Nigerian medicinal plants contain bioactive compounds with potentials of antibacterial activity and suggest that they could be employed as alternative in the treatment of bacterial infections after safety profiles is appraised.

کلیدواژه‌ها

Antibiotic resistance؛ Antibacterial؛ Medicinal plants؛ Nigerian؛ Systematic literature review

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