A Novel Cobalt Organic-Inorganic Hybrid Magnetic Nanocatalyst for Convenient Four-Component Synthesis of 3,4-Dihydropyridones

Iranian Journal of Catalysis

دوره 12، شماره 4، اسفند 2022، صفحه 417-429   

نوع مقاله: Articles

شناسه دیجیتال (DOI): 10.30495/ijc.2022.1959315.1938

نویسندگان

Maryam Barazandehdoust¹؛ Manouchehr Mamaghani^{* 2، 1}؛ Hassan Kefayati¹

¹Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

²Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

چکیده

Densely functionalized 3,4-dihydropyridones were synthesized by a four-component reaction of Meldrumʼs acid, ethyl acetoacetate, ammonium acetate, and proper aromatic aldehydes in the presence of novel organic-inorganic cobalt incorporated magnetic nanocatalyst (γ-Fe₂O₃@HAp/Co(II)) using ethanol as a green solvent at reflux condition. This new synthetic method provided the target compounds in a high yield (70-95%) and lower reaction time (20-75 min). The protocol benefits from the high purity of the products, environmentally friendly, milder reaction conditions, recyclability of the catalyst, and facile workup procedure. The structure of the synthesized novel nanocatalyst was confirmed by FT-IR, XRD, FSEM, TEM, EDS, and TGA analyses. The catalyst was used in eight cycles without any notable variation in catalytic activities.

کلیدواژه‌ها

3؛ 4-Dihydropyridone؛ One-pot؛ Four-component؛ Meldrumʼs acid؛ Nanocatalyst؛ γ-Fe2O3@HAp/Co(II)

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Supporting Information.pdf

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