Green synthesis of isoquinoline derivatives using mlticomponent reaction of ninhydrin

Iranian Journal of Organic Chemistry

دوره 15، شماره 1 - شماره پیاپی 57، اردیبهشت 2023، صفحه 3527-3531   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/iranjoc.2023.699824

نویسندگان

Samanehsadat Sharifi^* ؛ Narjes Haeizadeh

چکیده

In this work, The 1,3-dipolar intermediates generated by addition of isoquinoline to dialkyl acetylenedicaboxylates are trapped by ninhydrin to produce spiro compounds in excellent yields. In addition, for investigation of antioxidant ability radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product and catalyst.

کلیدواژه‌ها

Spiro compounds؛ Acetylenedicarboxylates؛ Ninhydrin؛ N-Heterocycles