Multi-Target Hybrid Drugs: A Promising Approach for Treating Alzheimer's, Neurological Diseases, Diabetes, and Cancer

Journal of Chemical Health Risks

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 تیر 1402   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2023.1982840.1718

نویسندگان

Armineh Rezagholi Lalani¹؛ Fariba Ebrahimbabaie²؛ Mohsen Sojoudi³؛ Nima Rastegar Pouyani⁴؛ Marzie Salari Sharifabad⁵؛ Fatemeh Fakhari⁴؛ Sepideh Rezaei^{* 6}

¹Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran

²Family Research Institute, Shahid Beheshti University, Tehran, Iran

³Department Operations Research (OR), Management Sciences at Ferdowsi University of Mashhad, Mashhad, Iran

⁴Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran

⁵Department of Pharmacy, International Campus, School of Pharmacy, Tehran University of Medical Science, Tehran, Iran

⁶Department of Chemistry, University of Houston, 3585 Cullen Blvd., Fleming Bldg. Rm 112, Houston, TX 77204-5003, USA

چکیده

Multi-target drugs are a class of hybrid compounds that can act on multiple targets and diseases simultaneously. These drugs have the potential to treat a range of disorders including Alzheimer's disease, diabetes, and cancer. This review aims to assess the efficacy of acridine- and tacrine-based multi-target hybrid drugs for the treatment of various diseases. In December 2022, a systematic literature search was conducted using "acridine," "tacrine," "multi-target agent, "and "multi-factorial diseases" along with their synonyms. According to the findings, acridine-based conjugates exhibited anti-cancer and anti-diabetic properties by directly inhibiting α-Glucosidase and α-Amylase, and by binding to DNA, topoisomerases, histone deacetylase, and poly (ADP-ribose) polymerase. The results suggest that acridine- and tacrine-based hybrid complexes have the potential to serve as promising multi-target agents for the treatment of Alzheimer's disease, neurological disorders, diabetes, and cancer. Overall, these compounds offer a new approach to drug development by targeting multiple disease pathways with a single agent. In conclusion, the use of multi-target drugs could potentially lead to improved therapeutic outcomes with fewer side effects, making them a promising area of research for the treatment of complex diseases. Keywords for this review include acridine, tacrine, multi-factorial diseases, and multi-target drugs.

کلیدواژه‌ها

Acridine؛ Tacrine؛ Multi-factorial diseases؛ Multi-target drugs

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