Serum miR-589-5p is related to biochemical recurrence after radical prostatectomy in prostate cancer patients

International Journal of Industrial Chemistry

دوره 13، شماره 1، خرداد 2022

نوع مقاله: research article

شناسه دیجیتال (DOI): 10.47176/IJIC.13.1.4

نویسندگان

Kaiqiang Chen¹؛ Jun Zhou¹؛ Yuri Kao¹؛ Qianhao Zhu¹؛ Yaowu Su¹؛ Weihua Liu^{* 2}

¹Department of Urology, Beilun People’s Hosptial, Ningbo City, Zhejiang Province, 315800, China

²Department of Urology, Beilun People’s Hosptial, Ningbo City, Zhejiang Province, 315800, China

چکیده

miRNAs manifested aberrantly suggest an association with prostate cancer (PCa) progression, such as biochemical recurrence (BCR). Therefore, we explored the correlation between serum miR-589-5p and postoperative BCR in PCa patients. Sixty PCa patients who underwent radical prostatectomy were included, and another 60 matched healthy male volunteers served as the normal control. Serum miR-589-5p was detected by RT-qPCR, and then its correlation with clinicopathological features of PCa patients was analyzed. Our results showed that serum miR-589-5p in PCa patients was decreased compared with normal control, and was associated with invasive clinicopathologic features, including high preoperative PSA, late pathological staging, poor Gleason score, lymph node metastasis, and BCR. In addition, reduced miR-589-5p was linked with shorter BCR-free survival and had prognostic application in PCa patients’ BCR-free survival. Our results indicated that miR-589-5p is suppressed in PCa patients with postoperative BCR, which has a clinical application to be a biomarker.

کلیدواژه‌ها

Prostate cancer؛ MiR-589-5p؛ Postoperative biochemical recurrence؛ Prognosis؛ Biomarker