Impacts of dexmedetomidine in association with sevoflurane anesthesia on postoperative pain along with recovery in elderly patients with lower limb fractures

International Journal of Industrial Chemistry

دوره 13، شماره 1، خرداد 2022

نوع مقاله: research article

شناسه دیجیتال (DOI): 10.47176/IJIC.13.1.8

نویسندگان

Pei Li¹؛ Lixiang Cao¹؛ Li Lv^{* 2}

¹Department of Anesthesiology Institute, Xiaoshan Traditional Chinese Medical Hospital, Hangzhou, 311201, Zhejiang, China

²Department of Anesthesiology Institute, Xiaoshan Traditional Chinese Medical Hospital, Hangzhou, 311201, Zhejiang, China.

چکیده

This study aimed to probe the influence of dexmedetomidine in association with sevoflurane anesthesia on postoperative pain and recovery in elderly lower limb fractures patients. A total of 120 elderly lower limb fractures patients received surgery were chosen and separated into control group (CG) and observation group (OG) following the random stratified sampling method. The OG adopted dexmedetomidine in association with sevoflurane anesthesia, and the CG adopted dexmedetomidine in association with propofol anesthesia. The hemodynamics indicators, sedation and analgesia, stress response, T helper cytokines levels, MMSE scores, along with incidence of adverse reactions in both groups were compared.
HR and MAP were increased and then decreased at T1-T4 in CG (P<0.05). VAS and Ramsay sedation scores at 6, 12 and 24h followed by operation in both groups continued to decrease (P<0.05). 24h after surgery, NE, E and Cor levels were elevated, and those in the OG were lessened (P<0.05). IFN-γ and TNF-α levels were declined, and those in the OG were elevated (P<0.05). The MMSE scores at 6, 12 and 24h followed by operation in CG were declined (P<0.05). There were obvious differences of MMSE scores between immediately after operation and 6, 12h followed by operation (P<0.05). The MMSE scores at 6, 12 and 24h followed by operation in the OG were elevated (P<0.05).
Dexmedetomidine combined with sevoflurane anesthesia is beneficial to protect the postoperative cognitive function of elderly lower limb fractures patients undergo surgical treatment and reduce postoperative pain to a greater extent.

کلیدواژه‌ها

lower limb fractures؛ dexmedetomidine؛ sevoflurane؛ anesthesia؛ stress response