A review on pharmacological potentials of phenolic diterpenes carnosic acid and carnosol obtained from Rosmarinus officinalis L. and modern extraction methods implicated in their recovery

Trends in Phytochemical Research

دوره 7، شماره 3، آذر 2023، صفحه 156-169   

نوع مقاله: Review article

شناسه دیجیتال (DOI): 10.30495/tpr.2023.1990761.1365

نویسندگان

Dhananjay Singh¹؛ Nishu Mittal²؛ Mohammed Haris Siddiqui^{* 3}

¹Department of Biosciences, Integral University, Kursi Road, Lucknow, Uttar Pradesh-226026, India

²Faculty of Biosciences, Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh-225003, India

³Department of Bioengineering, Integral University, Kursi Road, Lucknow, Uttar Pradesh-226026, India

چکیده

Rosmarinus officinalis L. is a perennial herb, known for culinary as well as medicinal properties. It has been shown that bioactive compounds like rosmarinic acid, carnosic acid, and carnosol are responsible for the medicinal properties of this plant species. Carnosic acid is a phenolic diterpene synthesized in young leaves of rosemary, whereas carnosol is produced after the oxidation of carnosic acid. Several studies have confirmed their antiangiogenic, anti-inflammatory, antimicrobial, antidiabetic, antioxidant, antitumor, neuroprotective, and gastroprotective properties. Ethanol, a mixture of ethanol-acetone, and hexane have been recommended as the best solvents for the extraction of carnosic acid, but advanced extraction techniques such as microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), etc. have been used to extract these phenolic antioxidant compounds in higher yield. This report is a kind of first study that emphasizes the recent research on the pharmacological potentials of carnosic acid and carnosol and summarizes the studies on modern extraction procedures. 

کلیدواژه‌ها

Bioactivities؛ Biological activity؛ Carnosic acid؛ Carnosol؛ Lamiaceae؛ Rosmarinus officinalis L؛ Secondary metabolites

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