Investigation of the Drug Delivery Potential of a Transdermal Patch Based on Buprenorphine Templated Molecular Imprinted Polymer

Journal of Applied Chemical Research

دوره 17، شماره 4، دی 2023، صفحه 46-62   

نوع مقاله: Original Article

نویسندگان

Nasrin Behnia¹؛ Parviz Aberoomand Azar^{* 1}؛ Maryam Shekarchi^{* 2}؛ Mohammad Saber Tehrani¹؛ Noushin Adib³

¹Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

²Food and Drug Laboratory Research Centre, Food and Drug Organization, MOH&ME, Tehran, Iran Pharmaceutical Research Center, Tehran University of Medical Science, Tehran, Iran

³Food and Drug Laboratory Research Centre, Food and Drug Organization, MOH&ME, Tehran, Iran

چکیده

To synthesize the molecular imprinted polymer (MIP), the well-known precipitation polymerization method was used. To do this, Methacrylic acid (MAA; as the functional monomer), ethylene glycol dimethacrylate (EGDMA; as the cross-linker), and 2,2-azobisissobutyronitrile (AIBN; as the initiator), were used. In addition, to control the release rate of Buprenorphine (BUP) from the patch, the bacterial cellulose (BC) was applied. The release process of the drug was investigated by high performance liquid chromatography(HPLC) system, which was showed to be fitted with the Higuchi expression. Moreover, the results have indicated that the obtained MIP-BC is a suitable candidate for the control released transdermal drug delivery. The work revealed that using MIP is more suitable compared to non-imprinted polymer (NIP). In addition, those results indicated that the MIP could be used as a patch for drug delivery application at least in the case of BUP drug.

کلیدواژه‌ها

Molecular imprinted polymer؛ Buprenorphine؛ Bacterial cellulose؛ Transdermal patch؛ Drug delivery. 

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