Investigation of the Potential of Adsorption and Drug Delivery Application of the Duloxetine Antipsychotic by using its Molecular Imprinted Polymer

Journal of Applied Chemical Research

دوره 18، شماره 1، فروردین 2024، صفحه 26-40   

نوع مقاله: Original Article

نویسندگان

Seyyedeh Fatemeh Hoseini chehreghani¹؛ Parviz Aberoomand Azar^{* 1}؛ Maryam Shekarchi^{* 2}؛ Bahram Daraei³

¹Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

²Food and Drug Laboratory Research Center, Food and Drug Organization, MOH & ME, Tehran, Iran Pharmaceutical Science Research Center, Tehran University of Medical Science, Tehran, Iran

³Department of Toxicology and Pharmacology, School of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

چکیده

The synthesis and application of a molecular imprinted polymer (MIP) as a carrier for drug delivery of Duloxetine (DUL) antipsychotic was investigated. Mimicking the natural receptors of DUL drug by synthesizing its MIP would lead to formation of some special active sites, which make able the MIP to accept only this special medicinal compound. Therefore, this MIP, which has been templated by DUL, could selectively absorb the molecules of DUL from the mediums in certain conditions and could release those chemical species in another place with different conditions. This MIP with its artificial receptors could be applied as a carrier for drug delivery applications and sustained released tablets. In order to synthesize this MIP based carrier, the precipitation polymerization method was applied. Also, methacrylic acid (MAA; as the functional monomer), 2,2-azobisissobutyronitrile (AIBN; as the initiator), and ethylene glycol dimethacrylate (EGDMA;
as the cross-linker), were applied to obtain this sorbent. Moreover, the release kinetics of the drug was investigated by HPLC system, which was shown to be fitted with the Higuchi expressionpattern at least at 5.8, and 6.8 pHs. Finally, the results revealed that the synthesized MIP is able to be used in formulation of the sustained released tablets.

کلیدواژه‌ها

Duloxetine؛ Molecular imprinted polymer؛ Release؛ Drug delivery؛ HPLC-UV. 

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