Antidiabetic and hypolipidaemic activities of Solenostemon monostachyus

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 3، دوره 6، شماره 2، آبان 2015، صفحه 85-92   

نوع مقاله: Original article

نویسندگان

Jude E. Okokon^{* 1}؛ Louis U. Amazu²؛ Lucky L. Nwidu³

¹Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo – Nigeria

²Department of Pharmacology and Therapeutics, College of Medicine, Evans Enwerem University, Orlu Campus, Imo State

³Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State

چکیده

Background & Aim: Solenostemon monostachyus has remain invincible in Ibibio ethnomedicine for the management of numerous ailment including diabetes mellitus. Many of these ethnomedicinal claims are yet to be pharmacologically verified. The purpose of this study therefore was to subject the extract/fractions of Solenostemon monostachyus used in folkloric management of diabetes to scientific assay. Experimental: The crude extract and fractions of S. monostachyus (75 -225 mg/kg) were evaluated for antidiabetic activity in alloxan – induced diabetic rats. The antidiabetic activity during acute and prolong studies were investigated. Glibenclamide, 10 mg/kg, was used as positive control. The Blood Glucose Level (BGL) was measured by using a glucometer and the various lipids level were estimated using Randox diagnostic kits. Results & Discussion: Treatment of alloxan diabetic rats with the extract/fractions caused a significant (P<0.001) reductions in BGL of the diabetic rats both in acute and prolong treatment (2 weeks). The activities of extract and fractions were comparable to that of glibenclamide in prolonged study. S. monostachyus treatment showed considerable lowering of serum total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and an increase in HDL cholesterol in the treated diabetic group. Industrial and practical recommendations: These results suggest that the extract of S. monostachyus possesses antidiabetic and hypolipidaemic effect on alloxan-induced diabetic rats which can be exploited in the management of diabetes.

کلیدواژه‌ها

Solenostemon monostachyus؛ antidiabetic؛ hypolipidemic؛ Diabetes

مراجع

Adebayo, J.O., Krettli, A.U. 2011. Potential antimalarials from Nigerian plants: A review. JEthnopharm., 133: 289 –302.

Ajibesin, K.K., Ekpo, B.A., Bala, D.N., Essien, E.E., Adesanya, S.A. 2008. Ethnobotanical survey of Akwa Ibom State of Nigeria. JEthnopharm 115: 387 – 408. 

Amaechi, D., Udosen, E.O., Edet, E.E., Asanga, E.E., Mbakwe, I.E. 2015. Lipid profile status of streptozotocin induced diabetic rats treated with ethanolic leaf extract of Solenostemon monostachyus. J.  Med Plts Res., 9(8): 289 – 293.

Amazu, L.U., Antia, B.S., Okokon, J.E. 2015. Antiulcer activity of Solenostemon monostachyus. The J. Phytopharmacol., 4(2): 97 – 101

Buisson, P. 1965. Plantes alimentaires de l’Ouest Africain: Etude botanique, biologique et chimique. Leconte, Marseille, France., 568 pp.

Datte, J.Y., Kpahe, F., Offoumou, A.M. 2010. Acute toxicity and antioxidant activity of hydroethanolic extract of Solenostemon monostachyus P. Beauv. Leaves. J compl integr med., Vol 7 Art. 45.

Djama, A.A., Kouassi Goffri, M.C., Koua, A.A., Ofosu, F.G., Aboh, I.J .2012. Heavy Metal Analysis of Some Anti-diabetic Medicinal Plants in Côte d'Ivoire. Current Research Journal of Biological Sciences., 4(5): 633-637.

Desai, P.D., Ganguly, A.K., Govindahari, T.R., Joshi, B.S., Kamat, V.N., Mande, A.H., Mohammed, P.A., Nagle, S.K., Nayak, R.H., Saksena, A.K., Sathe, S.S.,  Vishwanathan, N. 1966. Chemical investigation of some Indian plants; Part II. Ind J Chem., 4: 457.

Ekundayo, E.O., Ezeogu, L.I. 2006. Evaluation of antimicrobial activities of extracts of five plants used in traditional medicine in Nigeria. Intern. J. Trop. Med., 1: 93-96.

El-Hazmi, M.A., Warsy, A.S. 2001. Evaluation of serum cholesterol and triglyceride levels in 1-6-year-old Saudi children. Journal of Tropical Pediatrics., 47: 181-185.

Fidele, K.Z., Andre, K.B., Yao, D.J., Michel, O.A.2012. Action of hydroethanolic leaves extract of Solenostemon monostachyus (lamiaceae) on cardiovascular system of mammalians: blood pressure lowering effects. Intl JPharm Biol Sci., 2(3): 310-320.

Edduoks, M., Jouad, H., Maghrani, M., Lemhadri, A., Burcelin, R., 2003. Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularaia purpurea in streptozotocin mice. Phytomedicine 10:594 – 599.

Ghosal, S., Singh, A.K., Govindachari, T.R., Joshi, B.S., Kamat, V.N., Manmade, A.H., Mohammed, P.A., Nagle, S.K., Nayak, R.H., Saksena, A.K., Sathe, S.S., Vishwanathan, N. 1974. Chemical investigation of some Indian medicinal plants: Part II. Ind J Chem., 4: 457.

Hu, X., Sato, J., Oshida, Y., Xu, M., Bajotto, G., Sato, Y. 2003. Effect of Goshajinki-Gan(Chinese herbal medicine:Niu-Che-Sen-Qi-Wan) on insulin resistance in streptozotocin induced diabetic rats.Diabetes Res and Clin Pract., 59: 103 – 111.

Ivorra, M. D., Paya, M., Villar, A. 1989. A review of natural products and plants as potential antidiabetic agents. J. Ethnopharmacol., 27: 243-275.

Karawya, M.S., Wahab, S.A. 1984. Diphenylamine, an antihyperglycaemic agent from onion and tea.  J. Nat. Prod., 47: 775-780.

Krishnakumar, K., Augustti, K.T., Vijayammal, P.L. 2000. Hypolipidaemic effect of Salacia oblonga Wall. root bark in streptozotocin diabetic rats.  Med. Science 28: 65-67.

Kirtikar, K.R., Basu, B.D. 1999. Indian Medicinal Plants. 2nd edition. Bishen Sing Mahendra Pal Sing, Dehhradun, pp. 1655 – 1656.

Koffi, N., Marie –Solange, T., Emma, A.A., Noel, Z.G. 2009. Ethnobotanical study of plants used to reat arterial hypertension in traditional medicine, by abbey and Krobou population of Agboville (Cote d’ivoire).Eur. J. Sci. Res., 35: 85-98.

Mba, C.E., Menut, C. 1994. Aromatic plants of tropical Central Africa. Flav Frag J., 9: 315-317.

Mve-Mba, C.E., Menut, C., Lamaty, G., Zollo, P.H.A., Tchoumbougnang. 1994. Aromatic plants of tropical central Africa. Part XIX. Volatile components from leaves of two lamiaceae from Cameroon: Leucas deflexa Hook. and Solenostemon monostachyus (P.Beauv.) Briq. FlavFrag J.,  9(6): 315-317

N’Guessan, H.A., Dago, D.C.E., Mamyrbekova-Bekro, J.A., Békro, Y.A. 2011. CCM d’extraits selectifs de 10 plantes utilisées dans le traitement traditionnel de l’hypertension arterielle en Côte d’Ivoire. Eur J Sci Res., 66 (4): 575-585.

Mironova, M.A., Klein, R.L., Virella, G.T., Lopes-Virella, M.F. 2000. Antimodified LDL antibodies, LDL – containing immune complexes and susceptibility of LDL to in vitro oxidation in patients with type-2 diabetes. Diabetes., 49: 1033 – 1049.

Okoko, T., Ere, D. 2012. Antioxidant activities of Solenostemon monostachyus leaf extract using in vitro methods. Sci Res Essays., 7(6): 621-626.

Olabanji, S.O., Omobuwajo, O.R., Ceccato, D. 2008. Accelerator-based analytical technique in the study of some antidiabetic medicinal plants of Nigeria. Nucl. Instr. Meth. Phys. Res., 266: 2387-2390.

Pari, L., Amarnath, S. 2004. Antidiabetic activity of Boerhavia diffusa L.: effect on hepatic key enzymes in experimental diabetes. J. Ethnopharmacol., 91: 109-113.

Rajkumar,  L., Govindarajulu  P. 1991. Increased degradation of dermal collagen in diabetic rats.Ind J.Exp Biol, 29: 1081 – 1083.

Reher, G., Slijepcevic, M., Krans, L. 1991.Hypoglycaemic activity of triterpenes and tannins from Sarcopoterium spinosum and two Sanguisorba species. Planta. Med, 57:A57-A58.

Sofowora, A. 1993. Medicinal Plants and Traditional Medicine in Africa. 2nd ed. Spectrum Books Limited, Ibadan, Nigeria.

Tandon, S. 2005. Phytochemicals and cardiovascular health.Current R and D High., 28: 18 – 22.

Toshio, M., Peter, R., Conrad, H.E. 1980. Structures of six Coleons (Diterpenoids) from Solenostemon monostachyus (P. Beauv.) Briq. (Labiatae). Helvetica Chimica Acta- 63, Fasc.1-Nr.9

Tomoda, M., Shimada, K., Konno, C., Hikino, H. 1985.Structure of Panaxan B, A hypoglycaemic glycan of Panax ginseng roots. Phytochem,24:2431-2433.

Trease, G.E., Evans, W.C. 1989. Pharmacognosy. 13^th edn. Bailliere Tindall, London. P. 683-684.

WHO expert committee on diabetes mellitus. Tech. Rep. Series No.646.World Health Organisation, Geneva, 1980.