Histopathological evidences for effect beneficial of Satureja hortensis extract on hepatic lesion by cadmium–induced in Rat

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 5، دوره 6، شماره 2، آبان 2015، صفحه 101-107   

نوع مقاله: Original article

نویسندگان

Elham Moghtadai Khorasgani¹؛ Abdollah Ghasemi Pirbalouti^{* 2}؛ Sh. Adibi³

¹Department of Pathology, Faculty of Veterinary Medicine, Islamic Azad ‎University, Shahrekord Branch, Shahrekord, Iran

²Department of Medicinal Plants, Faculty of Agriculture, Islamic Azad ‎University, Shahrekord Branch, Shahrekord, Iran; Medicinal Plants Program, Collage of Natural Science, University of Massachusetts, Amherst, USA;

³Veterinary of Torabinejad Research Center, Isfahan University of Medical Science, Isfahan, Iran

چکیده

Background & Aim:Cadmium is an important industrial and environmental pollutant. Cadmium is one of the most toxic and carcinogenic heavy metals to organisms. This heavy metal mainly distributes to the liver and kidney in humans and animal and, causing acute hepatic injury. Experimental: The ethanol extract of Satureja hortensis L. (Lamiaceae family), was evaluated for its activity against cadmium–induced in male Wister rats (150 – 180 g). The ethanol extract of S. hortensis (100 and 200 mg/kg/day for six weeks) was examined on serum bicochemical and hepatic histopathological characteristic of rats subcutaneously received with cadmium chloride (CdCl₂) at 3 mg/kg/day for six weeks. Results: The biochemical results indicated that aspartate transminase (AST) and alanine transaminase (ALT) significantly increased in serum by cadmium–induced. The liver histopathological results revealed that the ethanol extract of S. hortensis treatment at 200 mg/kg/day significantly reduced toxicity by cadmium–induced. The ethanol extract of S. hortensis prevents the cadmium–induced lesions in hepatic function. Recommended applications/industries: Known antioxidant, antimicrobial, antihepatotoxic, nephroprotective potentials of the extract of S. hortensis may be the mechanisms by which this plant protects animals against experimentally cadmium–induced.

کلیدواژه‌ها

Cadmium؛ Medicinal herbs؛ aspartate transminase (AST)؛ alanine transaminase (ALT)؛ Liver histopathology

مراجع

Andersen, H.R., Andersen, O. 1988. Effect of cadmium chloride on hepatic lipid peroxidation in mice. Pharmacol Toxicol., 63: 173–177.

Bagchi, D., Joshi, S.S., Bagchi, M, Balmoori ,J., Benner, E.J., Kuszynski, CA., et al. 1999. Cadmium‐and chromium‐induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL‐60 cells, and normal human peripheral blood mononuclear cells.  J Biochem Mol Toxic., 14: 33–41.

Bharavi, K., Gopala Reddy, A., Rao, G.S., Ravikumar, P., Rajasekhar Reddy, A., Rama Rao, S.V. 2010. Reversal of cadmium induced oxidative stress and its bioaccumulation by culinary herbs Murraya koenigii and Allium sativum. Res J Pharmacol., 4: 60–5.

Borges, L.P., Brandão, R., Godoi, B., Nogueira, C.W., Zeni, G. 2008. Oral administration of diphenyl diselenide protects against cadmium–induced liver damage in rats. Chem Biol Interact., 171: 15–25.

Burt, S. 2004. Essential oils: their antibacterial properties and potential applications in foods. Int J Food Microbiol., 94: 223–53.

Dadfar, S., Ghasemi Pirbalouti, A., Mirlohi, M., Hojatelsami, M., Hamedi, B. 2012a. Antibacterial activity of the essential oils of endemic plants. J Herbal Drugs., 3: 35–40.

Dadfar, S., Ghasemi Pirbalouti, A.G., Mirloohi, M., Hojjatoleslami, M., Hamedi, B. 2012b. Antioxidant and antibacterial activity of essential oil of Iranian endemic medicinal herbs. Planta Med., 78: PI224.

Dorman, H.J.D., Hiltunen, R. 2003. Fe (III) reductive and free radical–scavenging properties of summer savory (Satureja hortensis L.) extract and subfractions. Food Chem., 88: 193–9.

El–Demerdash, F.M., Yousef, M.I., Kedwany, F.S., Baghdadi, H.H. 2004. Cadmium–induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β–carotene. Food Chem Toxicol., 42: 1563–71.

Ghasemi Pirbalouti, A. 2011. Medicinal and Aromatic Plants (Introduction and Application). 2^ed Ed., I.A.U. Press, Iran, pp. 551.

Goyer, R.A., Liu, J., Waalkes, M.P. 2004. Cadmium and cancer of prostate and testis. Biometals., 17:555–8.

Gupta, S., Athar, M., Behari, J.R., Srirastava, R.C. 1991. Cadmium mediated induction of cellular defence mechanism: a novel example for the development of adaptive response against a toxicant. Industrial Health., 29: 1–9.

Habeebu, S.S., Liu, J., Klaassen, C.D. 1998. Cadmium induced apoptosis in mouse liver. Toxicol Appl Pharm., 149: 203–9.

Hajhashemi, V., Ghannadi, A., Pezeshkian, S.K. 2002. Anti-nociceptive and anti–inflammatory effects of Satureja hortensis L. extracts and essential oil. Journal of Ethnopharmacology., 82: 83–7.

Hajhashemi, V., Sadraei, H., Ghannadi, A.R., Mohseni, M. 2000. Antispasmodic and anti–diarrhoeal effect of Satureja hortensis L. essential oil. J Ethnopharmacol., 71: 187–92.

Järup, L., Åkesson, A. 2009. Current status of cadmium as an environmental health problem.  Toxicol Appl Pharmacol., 238: 201–8.

Kara, E.E., Pirlak, U., Ozdilek, H.G. 2004. Evaluation of heavy metals’ (Cd, Cu, Ni, Pb, and Zn) distribution in sowing regions of potato fields in the province of Nigde, Turkey. Water Air Soil Poll., 153: 173–86.

Marchishin, S.M. 1983. Efficacy of the phenol compounds of Arnica in toxic lesion of the liver. Farmakol Toksikol., 46: 102–6.

Mihajilov–Krstev, T., Radnović, D., Kitić, D., Zlatkovič, B., Branković, S. 2009. Composition and antibacterial activity of S. hortensis L. essential oil. Cent Eur J Biol., 4: 411–6.

Milton Prabu, S., Muthumani, M., Shagirtha, K. 2012. Protective effect of Piper beetle leaf extract against cadmium–induced oxidative stress and hepatic dysfunction in rats. Saudi J Biol Sci., 19: 229–9.

Mozaffarian, V. 2008. A pictorial dictionary of botany botanical taxonomy; Latin – English – French – Germany – Persian/ Complied, Farahang Moaser, Tehran, pp. 522.

Nabulo, G., Oryem–Origa, H., Diamond, M. 2006. Assessment of lead, cadmium, and zinc contamination of roadside soils, surface films, and vegetables in Kampala City, Uganda. Environ Res., 101: 42–2.

Ozdemir, S., Dursun, S. 2009. Role of +(–) catechin against cadmium toxicity in the rat testes. Scand J Urol Nephrol., 43: 8–11.

Pari, L., Murugavel, P. 2005. Role of diallyl tetrasulfide in ameliorating the cadmium induced biochemical changes in rats. Environ Toxicol Phar., 20: 493–500.

Pavela, R., Sajfrtova, M., Sovova, H., Barnet, M. 2008. The insecticidal activity of Satureja hortensis L. extracts obtained by supercritical fluid extraction and traditional extraction techniques. Appl Entomol Zool., 43: 377–82.

Razzaghi–Abyaneh, M., Shams–Ghahfarokhi, M., Yoshinari, T., Rezaee, M.B., Jaimand, K., Nagasawa, H., et al. 2008. Inhibitory effects of Satureja hortensis L. essential oil on growth and aflatoxin production by Aspergillus parasiticus.  Int J Food Microbiol., 123: 228–33.

Renugadevi, J., Milton Prabu, M. 2009. Naringenin protects against cadmium–induced oxidative renal dysfunction in rats. Toxicol., 256: 128–34.

Santos, F.W., Zeni, G., Rocha, J.B., Weis, S.N., Fachinetto, J.M., Favero, A.M., et al. 2005. Diphenyl diselenide reverses cadmium–induced oxidative damage on mice tissues. Chem Biol Interact., 151: 159–65.

Stohs, S.J., Bagchi, D., Hassoun, E., Bagchi, M. 2000. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol., 19: 201.

Syers, J.K., Mackay, A.D., Brown, M.W., Currie, L.D. 1986. Chemical and physical characteristics of phosphate rock materials of varying reactivity. J Agric Food Chem., 37: 1057–64.

Taylor, M.D. 1997. Accumulation of cadmium derived from fertilizers in New Zealand soils. Sci Total Environ., 208: 123–6.

Tembo, B.D., Sichilongo, K., Cernak, J. 2006. Distribution of copper, lead, cadmium and zinc concentrations in soils around Kabwe town in Zambia. Chemosphere., 63: 497–501.

Uslu, C., Karasen, R.M., Sahin, F., Taysi, S., Akcay, F. 2003. Effects of aqueous extracts of Satureja hortensis L. on rhinosinusitis treatment in rabbit. J Ethnopharmacology., 88: 225–8.

Vinoth Kumar, P., Amala Bricey, A., Veerathamari Selvi, V., Sudheer Kumar, C., Ramesh, N. 2010. Antioxidant effect of green tea extract in cadmium chloride intoxicated rats. Advan Appl Sci Res., 1:9–13.

Waisberg, M., Joseph, P., Hale, B., Beyersmann, D. 2003. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicol ., 192: 95–117.

Zargari, A. 1990. Medicinal Plants. Tehran University Press, Tehran, Iran.

Zhai, L., Liao, X., Chen, T., Yan, X., Xie, H., Wu, B., et al. 2008. Regional assessment of cadmium pollution in agricultural lands and the potential health risk related to intensive mining activities: A case study in Chenzhou City, China. J Environ Sci., 20: 696–703.

Zitkevicius, V., Smalinskiene, A., Savickiene, N., Savickar, A., Ryselis, S., Sadauskiene, I., et al. 2011. Assessment of the effect of Echinacea purpurea extract on the accumulation of cadmium in liver and kidney; apoptotic–mitotic activity of liver cells. J Med Plants Res., 5: 743–50.