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Hosseinzadeh Sahafi, Homayoun, Soltani, Mehdi, Hosseini Shekarabi, Seyed Pezhman. (1397). Endocrine disrupting effects of 4-nonylphenol on plasma vitellogenin, reproductive system and histology in koi carp (Cyprinus carpio). نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 10(3), 263-274. doi: 10.1007/s40071-018-0203-8
Homayoun Hosseinzadeh Sahafi; Mehdi Soltani; Seyed Pezhman Hosseini Shekarabi. "Endocrine disrupting effects of 4-nonylphenol on plasma vitellogenin, reproductive system and histology in koi carp (Cyprinus carpio)". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 10, 3, 1397, 263-274. doi: 10.1007/s40071-018-0203-8
Hosseinzadeh Sahafi, Homayoun, Soltani, Mehdi, Hosseini Shekarabi, Seyed Pezhman. (1397). 'Endocrine disrupting effects of 4-nonylphenol on plasma vitellogenin, reproductive system and histology in koi carp (Cyprinus carpio)', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 10(3), pp. 263-274. doi: 10.1007/s40071-018-0203-8
Hosseinzadeh Sahafi, Homayoun, Soltani, Mehdi, Hosseini Shekarabi, Seyed Pezhman. Endocrine disrupting effects of 4-nonylphenol on plasma vitellogenin, reproductive system and histology in koi carp (Cyprinus carpio). نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1397; 10(3): 263-274. doi: 10.1007/s40071-018-0203-8

Endocrine disrupting effects of 4-nonylphenol on plasma vitellogenin, reproductive system and histology in koi carp (Cyprinus carpio)

International Aquatic Research
مقاله 5، دوره 10، شماره 3، آذر 2018، صفحه 263-274    اصل مقاله (14.67 M)
نوع مقاله: Original research
شناسه دیجیتال (DOI): 10.1007/s40071-018-0203-8
نویسندگان
Homayoun Hosseinzadeh Sahafi1؛ Mehdi Soltani2، 3؛ Seyed Pezhman Hosseini Shekarabi4
1Iranian Fisheries Science Research Institute Agriculture Research, Education and Extension Organization, Tehran, Iran
2Present address: Freshwater Fish Group and Fish Health Unit, School of Veterinary and Life Science, Murdoch University, Perth, Australia
3Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
4Department of Fisheries Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
This study aimed to assess the effect of 4-nonylphenol (4-NP), a ubiquitous aquatic micro-chemical pollutant substance on some on some reproductive parameters and histology in koi carp. Fish were intraperitoneally subjected to ascending doses of 4-NP at 10, 50 and 100 μg/g body weight (BW) on days 7, 14 and 21 after the initiation of the experiment. Also, one group was treated with 17β-estradiol (E2) at 2 μg/g BW, positive control group (C2) received the vehicle (50 μL of coconut oil + 50 μL Ethanol) per fish and a negative control group (C1) was considered without injection. The results showed that 4-NP induced significantly an increase in E2, progesterone, and plasma vitellogenin at 50 μg/g in both male and female, while level of testosterone significantly decreased in the treated fish compared to control fish (P < 0.05). Conversely, the levels of these parameters at the higher concentration of 4-NP (100 μg/g) were significantly reduced compared to control one (P < 0.05). Also, some sever histopathological changes were observed in ovary, testicular and liver of treated fish, reflecting fish sensitivity to 4-NP at higher doses. This study showed that 4-NP has an estrogenic potency in the sexual development, hepatotoxicity and gonado-toxicity of koi carp.
کلیدواژه‌ها
Nonylphenol؛ Reproductive system؛ Vitellogenin؛ Histopathology؛ Koi carp
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